Gonadorelin CAS:33515-09-2

 

Gonadorelin is used by women who are missing menstrual periods due to low levels of gonadotropin-releasing hormone (GnRH). It may be used as part of female infertility treatment. This medication provides GnRH that the body needs for the growth and release of mature eggs from the ovaries (ovulation).

GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults.

Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.

Gonadorelin is used as a diagnostic agent to assess pituitary gland function. It is also used in the treatment of primary hypothalamic amenorrhea, hypogonadotropic hypogonadism (e.g., Kallmann syndrome), delayed puberty, cryptorchidism, and infertility.Unlike other GnRH analogues, it is not used to suppress sex hormone production.

 

 

 

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Gonadorelin, used as a test, has been studied only in children 12 years of age and older. The medicine has not caused different side effects or problems in children 12 years of age and older than it does in adults. Children up to 12 years of age may not be sensitive to the effects of gonadorelin. Infants may be very sensitive to the effects of gonadorelin and use in infants is not recommended.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

 

 

● Adults and Elderly

100 micrograms, subcutaneously or intravenously. In females for whom the phase of the menstrual cycle can be established, the test should be performed in the early follicular phase (days 1-7).

● Paediatric population

The safety and efficacy of gonadorelin in children under one year have not been established. No data are available.

● Route of administration

For subcutaneous and intravenous administration.For instructions on reconstitution before administration, see section 6.6.

● Test Methodology

To determine the status of the gonadotropin secretory capacity of the anterior pituitary, a test procedure requiring seven venous blood samples for LH is recommended.

Gonadorelin has a distribution half-life of 2 to 10 minutes and a very short terminal half-life of 10 to 40 minutes.It is metabolized by hydrolysis into smaller peptide components

 

 

Although allergic and hypersensitivity reactions have been observed with other polypeptide hormones, to date no such reactions have been encountered following the administration of a single 100 micrograms dose of gonadorelin used for diagnostic purposes. Rare instances of hypersensitivity reactions have been reported. Therefore, patients in whom re-administration is considered, particularly by the intravenous route, should be carefully observed. Administration during the follicular phase of a normal cycle may result in premature ovulation and appropriate measures are advised to prevent an unwanted pregnancy in these circumstances.

Gonadorelin and its analogues are not recommended for use in patients with pituitary adenoma as haemorrhagic infarction (pituitary apoplexy) may occur.

 

 

The gonadorelin test should be conducted in the absence of other drugs which directly affect the pituitary secretion of gonadotropins. These would include a variety of preparations which contain androgens, oestrogens, progestogens or glucocorticoids.

The gonadotropin levels may be transiently elevated by spironolactone, minimally elevated by methyldopa, and suppressed by oral contraceptives and digoxin.

The response to gonadorelin may be blunted by phenothiazines and dopamine antagonists which cause a rise in prolactin.

 

 

Product Name	Factrel, HRF, Kryptocur, Lutrelef, Lutrepulse, Relefact, Abbott 41070; AY-24031; Hoe-471; RU-19847
CAS	33515-09-2
Molar mass	1182.311
MF	C55H75N17O13
Capacity/Bottle	2mg/vial
Shape	Lyophilized powder

 

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Gonadotropins are hormones that play a crucial role in the regulation of reproductive functions in both males and females. In males, gonadotropins, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH), have several important functions:

 

Stimulation of Testosterone Production: LH acts on the Leydig cells in the testes to stimulate the production of testosterone, the primary male sex hormone. Testosterone is essential for the development and maintenance of male sexual characteristics, including the growth of facial and body hair, deepening of the voice, and the development of the male reproductive organs.

Spermatogenesis: FSH plays a key role in spermatogenesis, the process by which sperm cells are produced in the testes. FSH stimulates the Sertoli cells within the testes, which, in turn, support the maturation and development of sperm cells. Without FSH, proper sperm production would not occur.

Regulation of Testicular Size: LH and FSH also help regulate the size and function of the testes. LH, through its action on Leydig cells, helps maintain testicular size and function by promoting testosterone production. FSH, through its action on Sertoli cells, supports the maturation and development of sperm within the testes.

Maintenance of Libido and Sexual Function: Testosterone, which is stimulated by gonadotropins, plays a significant role in libido (sex drive) and overall sexual function in males.

In summary, gonadotropins, specifically LH and FSH, are critical for the normal functioning of the male reproductive system. They regulate testosterone production, sperm production, and overall sexual health. Dysregulation of gonadotropin levels can lead to various reproductive health issues in males, including infertility and hormonal imbalances.

 

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