Kisspeptin CAS:374675-21-5

 

Kisspeptin is a protein present in the hypothalamus (a part of the brain that controls the release of several important hormones in the body). Kisspeptin plays a major role in the control of reproductive hormones in both men and women. Specifically, kisspeptin regulates the release of 'gonadotrophin releasing hormone' (GnRH) from the hypothalamus. GnRH, in turn, stimulates the release of the hormones, luteinising hormone (LH) and follicle stimulating hormone (FSH) from the pituitary gland, into the blood stream. These two hormones act on the testes in men and ovaries in women to produce sex-steroids, namely testosterone in men and oestradiol in women. Testosterone and oestradiol are the hormones responsible for the physical and emotional changes that occur during puberty in order to transition into adulthood.

Kisspeptin has a non-hormonal role too and was originally named 'metastin' due its ability to prevent the spread of cancer (metastasis).

 

 

 

Kisspeptin is released from nerve cells in the hypothalamus, together with two other proteins, neurokinin B and dynorphin. Consequently, the nerve cells making Kisspeptin, Dynorphin and Neurokinin B are popularly referred to as 'KNDy' (pronounced 'candy'). It is believed that these proteins act in concert to induce the release of GnRH in a pulsating manner, which is important for its ability to stimulate LH and FSH.

 

 

Rarely, excess activity of kisspeptin in the hypothalamus due to genetic differences in some people can cause early puberty, also known as precocious puberty. Some studies have suggested that blood levels of kisspeptin are increased in children with precocious puberty.

 

 

Thankfully, the lack of kisspeptin action in the hypothalamus due to abnormalities in the relevant genes responsible are rare. When present, a lack of kisspeptin action in the hypothalamus results in insufficient GnRH, and in turn LH and FSH, and eventually a lack of testosterone (men) or oestradiol (women), which is a condition called 'hypogonadotrophic hypogonadism'. Children with hypogonadotrophic hypogonadism due to genetic causes (called 'congenital hypogonadotrophic hypogonadism') are unable to proceed through puberty naturally and need hormone treatments to be able to do so.

Kisspeptin's action in the hypothalamus can also be reduced due to other reasons aside from genetic causes to result in decreased reproductive function. One such example in which kisspeptin's action in the hypothalamus is reduced, is called 'hypothalamic amenorrhoea'. Amenorrhoea means a lack of periods. 'Hypothalamic amenorrhoea' is a specific type of amenorrhoea that occurs due to factors that can reduce the normal function of the hypothalamus, such as stress or insufficient energy availability. Research has suggested that in light of kisspeptin's ability to stimulate the hypothalamus to secrete GnRH, giving kisspeptin could be used to restore reproductive health in women with hypothalamic amenorrhoea.

 

 

● Increases testosterone levels

● Lowers the risk of heart disease

● Boosts immunity

● Helps lose weight

● Prevents wrinkles and other signs of skin aging

● Prevents cancer

● Boosts brain power

● Treats fertility disorders

 

 

Kisspeptin is supplied as a dry powder for injections.
Standard dosing:

100 mcg subQ daily (10 units by Insulin syringe)

Others advocate for use along with TRT dosing 2-3 times a week

Ideally, the patient will take his kisspeptin-10 dosage concurrently with TRT, typically 2-3 times per week with a standard injection of . 1-. 2mL per injection at each interval.

 

 

Product Name	KISS1, HH13, KiSS-1, KiSS-1 metastasis-suppressor, KiSS-1 metastasis suppressor
CAS	374675-21-5
Molar mass	1302.44
MF	C63H83N17O14
Capacity/Bottle	2mg/vial
Shape	Lyophilized powder

 

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Kisspeptin is a neuropeptide (a type of signaling molecule in the nervous system) that plays a crucial role in regulating the reproductive system. It is primarily produced in the hypothalamus, a region of the brain that controls many physiological processes, including the secretion of hormones involved in reproduction.

The primary function of kisspeptin is to stimulate the release of two key hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones, in turn, play essential roles in regulating the reproductive system:

Stimulating Puberty: During puberty, there is an increase in kisspeptin production. This increase in kisspeptin levels is thought to be one of the triggers that initiate the onset of puberty. Kisspeptin stimulates the release of LH and FSH, which are responsible for the development of secondary sexual characteristics, such as the growth of breasts and the maturation of the testes.

Regulating the Menstrual Cycle: In females, kisspeptin helps control the menstrual cycle. It prompts the release of LH and FSH, which are necessary for the development of ovarian follicles, the release of eggs (ovulation), and the production of sex hormones like estrogen and progesterone.

Supporting Reproduction: Kisspeptin is crucial for maintaining normal reproductive function in both males and females. It ensures the timely release of LH, which is necessary for the production of testosterone in males and for ovulation and the maintenance of the menstrual cycle in females.

Controlling Gonadotropin-Releasing Hormone (GnRH): Kisspeptin acts by stimulating the release of GnRH, another hormone produced by the hypothalamus. GnRH, in turn, regulates the secretion of LH and FSH from the pituitary gland.

Kisspeptin's role in regulating the reproductive system is highly interconnected with other hormones, and its precise function can vary depending on an individual's stage of development and reproductive status. Abnormalities in the kisspeptin system can lead to reproductive disorders, such as delayed or absent puberty and infertility. Research into kisspeptin continues to expand our understanding of how it influences human reproduction and provides potential avenues for the treatment of reproductive-related disorders.

 

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