Methyltrienolone(Metribolone)Raw Material Powder For Bodybuilding CAS:965-93-5

   What is Methyltrienolone (Metribolone)?

    Methyltrienolone is a synthetic, orally active anabolic-androgenic steroid (AAS) derived from nandrolone (19-nortestosterone). Its chemical designation is 17α-methyltrienolone, and it is often considered the most potent oral steroid ever synthesized. The "trienolone" portion of its name refers to its chemical structure, which features three double bonds in the A-ring (specifically, between carbon atoms 1 and 2, 3 and 4, and 9 and 10) and a 17α-methyl group that allows it to survive first-pass liver metabolism, granting oral bioavailability.

    Originally developed in the 1960s by the pharmaceutical company Roussel Uclaf, its intended application was as a research tool for studying androgen receptors due to its exceptionally high binding affinity. It was never approved for human therapeutic use because its toxicity profile was deemed unacceptable for medicine. In the bodybuilding underground, it is a legendary, almost mythical compound, reserved for pre-competition phases by professional bodybuilders seeking the ultimate in hardness, density, and muscle definition.

    The features of Methyltrienolone are what define its extreme nature:

    1.Unmatched Receptor Binding Affinity: Metribolone has an affinity for the androgen receptor (AR) that is significantly higher than that of dihydrotestosterone (DHT) and several orders of magnitude greater than testosterone. This means it binds to muscle tissue receptors with incredible strength and efficiency, initiating a massive anabolic signal.

    2.Non-Aromatizable: Its structure is incapable of being converted into estrogen via the aromatase enzyme. This means users do not have to worry about estrogenic side effects like gynecomastia or significant water retention. In fact, it has anti-estrogenic properties.

    3.Progestogenic Activity: Despite being derived from nandrolone, its binding to the progesterone receptor is potent. This can synergistically enhance the androgenic signal but also significantly increase the risk of progestogenic side effects, including severe suppression of natural testosterone production and progestin-related gynecomastia.

    4.17-alpha alkylation (17α-methylation): This structural modification is what allows the compound to be taken orally. However, it is also the primary reason for its extreme hepatotoxicity (liver toxicity), making it one of the most liver-toxic steroids in existence.

    5.Extreme Androgenicity: Its powerful androgenic nature means it can cause rapid and severe androgenic side effects, including oily skin, acne, accelerated male pattern baldness, and aggressive body hair growth.

    The application of Methyltrienolone is singular and highly specialized: to produce a dramatic, dry, and grainy physique in the final weeks before a bodybuilding competition.

    ●Extreme Hardness and Density: Its primary benefit is its ability to drastically increase muscle hardness and density. By creating a profound anabolic environment without any water retention, it makes muscles appear carved from stone, with striations and separation becoming exceptionally visible.

    ●Massive Strength Increases: Users often report staggering increases in strength over a very short period, even when in a significant caloric deficit. This helps competitors maintain intense training volume and intensity while dieting.

    ●Glycogen Supercompensation: It may enhance the muscle cells' ability to pull in and hold glycogen, contributing to a full, hard, and vascular look when combined with carbohydrate manipulation protocols.

    ●Fat Loss: Its strong metabolic activity can contribute to an increased metabolic rate, aiding in the final stages of fat loss. Its ability to bind to glucocorticoid receptors may also help inhibit the catabolic effects of cortisol, which is elevated during intense dieting.

    It is crucial to understand that Metribolone is not a mass-building drug. Its use is purely for refining an already exceptionally lean and developed physique.

    Handling Methyltrienolone requires an understanding that "less is more" is a critical principle.

    ●Dosage: Due to its extreme potency, dosages are measured in micrograms (mcg), not milligrams (mg). The typical effective dose ranges from 250 mcg to a maximum of 1000 mcg (1 mg) per day. Very few individuals ever approach the 1 mg mark. Starting at the absolute lowest possible dose (250-500 mcg) is mandatory to assess tolerance. Exceeding these minuscule amounts exponentially increases the risk of severe side effects with diminishing returns.

    ●Cycle Length: The hepatotoxicity dictates an extremely short duration of use. A typical cycle lasts no more than 2 to 4 weeks. It is almost exclusively used in the final 2-3 weeks leading up to a show. Running it for longer is an invitation for serious liver damage.

    ●Half-Life: Methyltrienolone has a relatively short half-life, estimated to be between 4 to 6 hours. This necessitates splitting the daily dose into 2-3 administrations throughout the day to maintain stable blood levels.

    A sample protocol for an experienced competitor might look like this:

    ●Weeks 1-2: 500 mcg daily, split into two doses of 250 mcg (e.g., morning and evening).

    ●Final Week (peak week): May adjust based on look, but rarely exceeds 750 mcg.

    It is almost never used as a standalone compound. It is typically incorporated into a sophisticated "contest prep" stack that may include other non-aromatizing compounds like Masteron, Trenbolone, and Winstrol, alongside a base of exogenous testosterone (often at a low dose) or TRT.

    The concept of Post-Cycle Therapy (PCT) after a Methyltrienolone cycle is almost irrelevant in the traditional sense because its use is so suppressive. The hormonal devastation it causes is near-total and rapid.

    ●Suppression: Within days, natural testosterone production will be completely shut down due to its potent effect on the hypothalamic-pituitary-testicular axis (HPTA).

    ●PCT Difficulty: Standard PCT protocols using SERMs like Clomid (Clomiphene Citrate) and Nolvadex (Tamoxifen) are often insufficient to restart natural production after such a powerful compound. The body may struggle to recover for a prolonged period.

    ●The Reality for Users: Most individuals who use a compound of this caliber are advanced bodybuilders who are either:

    1.Already on a "blast and cruise" protocol, meaning they will not undergo PCT but will instead "cruise" on a TRT dose of testosterone after their contest to allow their body (primarily their liver) to recover before their next "blast."

    2.Heading into a pre-competition phase where other compounds will keep them suppressed, making immediate PCT after the show unlikely.

    Attempting a standard PCT after a Metribolone cycle is a gamble with a very high chance of failure, leading to prolonged low-testosterone symptoms like depression, fatigue, loss of libido, and muscle loss.

    The benefits of Methyltrienolone come at a dire cost. Its side effect profile is arguably the worst among all steroids.

    1.Extreme Hepatotoxicity: This is the most significant danger. It causes acute and severe stress to the liver, drastically elevating liver enzymes (AST, ALT). Jaundice (yellowing of the skin and eyes) and liver damage are genuine risks even with short-term use. Concomitant use of other oral steroids or liver-toxic substances (like alcohol or acetaminophen) is exceptionally dangerous. Liver support supplements (e.g., TUDCA, NAC) are not a guarantee of safety but are an absolute necessity.

    2.Cardiovascular Strain: It can negatively impact lipid profiles, causing a dramatic reduction in HDL (good cholesterol) and an increase in LDL (bad cholesterol). This poses a significant long-term risk for atherosclerosis and cardiovascular disease.

    3.Progestogenic Side Effects: Despite not aromatizing, it can still cause gynecomastia due to its activity at the progesterone receptor. This type of gyno can be particularly stubborn to reverse.

    4.Androgenic Side Effects: Hair loss, acne, and oily skin can be severe and occur very rapidly.

    5.Insomnia and "Tren Cough": Many users report severe insomnia and anxiety. Notably, it can cause a phenomenon similar to "Tren cough"-a sudden, intense, and dry coughing fit shortly after administration, believed to be related to its effect on pulmonary receptors.

    6.Lethargy and General Toxicity: The systemic stress and liver strain often manifest as profound lethargy and a general feeling of being unwell.

Trade names	Methyltrienolone, 17α-Methyltrenbolone; R1881; R-1881; RU-1881; NSC-92858; 17α-Methyl-19-nor-Δ9,11-testosterone; 17α-Methylestra-4,9,11-trien-17β-ol-3-one
CAS	965-93-5
Molar mass	284.399
Formula	C19H24O2
Purity	Above 98%
Apprarance	White  Crystalline Powder

 

 

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    Methyltrienolone raw material powder is the apotheosis of anabolic potency-a compound that exists at the furthest extreme of the risk-reward spectrum. It is a tool that can chisel a physique into its ultimate, grainy, and conditioned form but does so by wielding a toxic hammer against the user's own biology.

    Its application is so niche that it borders on obscurity, reserved for a tiny fraction of the competitive bodybuilding elite who are willing to gamble short-term health for a competitive edge. For the overwhelming majority of athletes, even experienced ones, the risks associated with Metribolone catastrophically outweigh any potential benefit. The existence of other, less toxic compounds that can achieve similar goals (e.g., Masteron, Oral Turinabol, Anavar) makes the choice to use Methyltrienolone one of the most consequential and dangerous decisions in all of performance enhancement. It stands as a stark reminder of the extreme lengths pursued in the sport and the profound physiological cost that often accompanies it.

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