Testosterone Undecanoate
Testosterone undecanoate, sold under the brand names Andriol and Aveed among others, is an androgen and anabolic steroid (AAS) .It can promote male growth, male secondary sex characteristics and the development of testis and accessory gonad structures. Promote protein synthesis and reduce breakdown, enhance immune function, promote bone growth. Promote erythropoiesis, feedback inhibition of gonadotropin secretion, inhibition of estrogen secretion.
Product Name: Testosterone Undecanoate
Brand Name (if applicable): [Brand Name]
Active Ingredient: Testosterone Undecanoate
Strength: [e.g., 40 mg, 1000 mg, etc.]
Presentation: [e.g., Soft gel capsules]
Testosterone Undecanoate is a synthetic form of the male sex hormone testosterone. It is formulated as a soft gel capsule for oral administration. Each capsule contains a specific amount of testosterone undecanoate, which is an esterified form of testosterone.
Indications:
Testosterone Undecanoate is indicated for hormone replacement therapy (HRT) in adult males with hypogonadism, a condition characterized by low levels of endogenous testosterone production. It is used to supplement the body with testosterone and alleviate symptoms associated with testosterone deficiency.
structural features
Testosterone undecanoate is a modified form of testosterone in which a carboxylate (undecanoic acid) has been attached to the 17-beta hydroxyl group. The esterified form of testosterone is less polar than free testosterone and is absorbed more slowly in the injected area. Once in the blood, the ester is removed to produce free (active) testosterone. The esterified form of testosterone is designed to prolong the window of therapeutic effect after administration, allowing for a less frequent injection regimen compared to injecting free (non-esterified) steroids. Nebido is designed to maintain physiological levels of testosterone for up to 14 weeks after injection.
indications
1)Primary or secondary testicular hypofunction;
2) Constitutional delayed puberty in boys;
3) Palliative treatment of breast cancer metastasis;
4) Adjuvant therapy for aplastic anemia;
5)Partial androgen deficiency syndrome in middle-aged and elderly people;
6) Rheumatoid arthritis.
doasge
It must be used under the guidance of a specialist. The starting dose is 120-160mg (3-4 capsules) per day, and after two weeks of medication, the daily dose is maintained at 40-120mg (1-3 capsules). Twice in the morning and evening, orally after meals. If you take an odd number of capsules per day, take 1 more capsule in the morning, or follow the doctor's advice.
Pharmacokinetics
After oral administration, the drug is absorbed in the lymphatic vessels of the small intestine in the form of chylomicrons, enters the systemic circulation through the thoracic duct, and releases testosterone after ester bond cleavage. This form of absorption avoids the liver's first-pass effect and hepatotoxicity. The peak time of serum testosterone after oral administration has obvious individual differences, with an average of about 4 hours. After continuous administration, the serum testosterone level gradually increases and reaches a steady state after 2 to 3 weeks; after a single intramuscular injection, the serum testosterone peak time is about 7 days, and returns to the level before intramuscular injection after 21 days. This product is a lipophilic drug, after oral administration, it is absorbed through the lymphatic system together with lipids, with large individual differences, tmax is 1 to 8 hours, and the average is 4 hours. Excreted through urine, the total amount in urine within 1 week after taking the drug is 45% to 48%, and 40% of the absorbed dose within 24 hours appears in urine.
Clinical data
|
Trade names |
Oral: Kyzatrex, Andriol, Jatenzo, others IM: Aveed, Nebido |
|
Other Name |
TU; Testosterone undecylate; Testosterone 17β-undecanoate; ORG-538; CLR-610 |
|
CAS |
5949-44-0 |
|
Molar mass |
456.711 |
|
MF |
C30H48O3 |
|
Purity |
Above 98% |
|
Apprarance |
White crystalline powder |
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