STROMUSC Andarine S4 Tablets For Bodybuilding CAS:401900-40-1

   What is Andarine S4?

    Andarine S4 is an investigational SARM initially developed by GTx, Inc. (now Oncternal Therapeutics) for potential therapeutic applications like treating muscle wasting (cachexia), osteoporosis, and benign prostatic hyperplasia (BPH). Its core mechanism lies in its selectivity. While traditional anabolic steroids activate androgen receptors (ARs) indiscriminately throughout the body (muscle, bone, prostate, liver, skin, hair follicles, brain), S4 was designed to preferentially bind to and activate ARs in muscle and bone tissue, while exhibiting significantly less activity (acting as an antagonist or partial agonist) in tissues like the prostate and sebaceous glands. This selectivity forms the theoretical basis for its appeal: promoting anabolism where desired, minimizing unwanted androgenic effects elsewhere. Chemically, it's known as (2S)-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide.

    S4 possesses several unique characteristics setting it apart from other SARMs and steroids:

    ●Partial Agonism: Unlike many SARMs that are full agonists at the muscle AR, S4 is a partial agonist. This means its maximum stimulatory effect on the muscle AR is inherently lower than a full agonist like testosterone or RAD-140. While this might suggest less potent muscle growth, it contributes to its tissue selectivity profile.

    ●Tissue-Selective Modulation: Its partial agonism manifests differently across tissues. It acts as a relatively strong agonist in muscle and bone, but a weak agonist or even antagonist in prostate tissue, potentially mitigating prostate enlargement risks associated with androgens.

    ●Unique Side Effect - Visual Disturbance (The "Yellow Tint"): S4 is infamous for causing a dose-dependent, transient visual side effect. Users often report a yellowish tint to their vision, particularly noticeable in low-light conditions or transitioning between light and dark environments. This is believed to be due to S4 interacting with retinaldehyde-binding protein 1 (RLBP1) in the retina, temporarily affecting rhodopsin regeneration (a key visual pigment). This effect usually reverses within days of cessation but is a significant practical consideration.

    ●Relatively Short Half-Life: With a half-life estimated around 4-6 hours, S4 requires more frequent dosing compared to SARMs like Ostarine (MK-2866) or LGD-4033.

    ●Potential for Fat Loss: Beyond muscle building, S4 exhibits a stronger propensity for promoting fat loss compared to some other SARMs, likely linked to its modulation of metabolic pathways via AR activation in muscle and potentially adipose tissue.

    Bodybuilders leverage S4 for specific goals where its unique profile offers advantages:

    ●Lean Muscle Accretion & Hardening: S4 excels at promoting lean, dense, "dry" muscle gains. It doesn't typically cause significant water retention, leading to a harder, more vascular appearance. This makes it popular during cutting phases or recomposition periods.

    ●Fat Loss Catalyst: Its ability to enhance metabolic rate and promote lipolysis makes it a valuable tool during fat-loss phases, helping preserve muscle mass while shedding fat. Users often report enhanced vascularity and muscle definition.

    ●Strength Enhancement: Significant increases in strength are commonly reported, supporting more intense training and further muscle stimulation.

    ●Muscle Preservation During Caloric Deficits: Its anti-catabolic properties help protect hard-earned muscle when calories are restricted, crucial during contest prep or aggressive cuts.

    ●"Conditioning" Phase Tool: Due to its hardening and fat-loss effects, S4 is frequently incorporated in the final weeks leading up to a bodybuilding competition to achieve peak muscle definition.

    The theoretical and reported benefits of S4 stem from its SARM mechanism:

    ●Increased Lean Muscle Mass: Stimulates protein synthesis and inhibits protein breakdown via AR activation in muscle.

    ●Reduced Body Fat: Enhances metabolic activity and promotes lipolysis.

    ●Enhanced Strength: Supports neural drive and muscle fiber contractility.

    ●Improved Bone Density: Beneficial AR activation in bone tissue (though less relevant for healthy young bodybuilders).

    ●Potential Reduction in Traditional Steroid Side Effects: Theoretically lower risk of androgenic alopecia (hair loss), severe acne, and prostate enlargement compared to traditional steroids due to tissue selectivity. Crucially, this does NOT equate to being side-effect free.

    ●Non-Esterified/Oral Bioavailability: Unlike many injectable steroids, SARMs like S4 are orally bioavailable.

    Dosing S4 requires careful consideration due to its visual side effect:

    ●Common Range: 25mg to 75mg per day, divided into multiple doses due to its short half-life.

    ●Titration is Crucial: It is highly recommended to start at the lower end (e.g., 25mg/day split into 2 doses) and gradually increase every 1-2 weeks ONLY if the visual side effect is tolerable and results plateau. Many users find their optimal dose where visual disturbance is minimal (often a slight yellow tint only noticeable in darkness) but effects are significant, frequently between 35mg and 50mg per day.

    ●Dosing Schedule: Typically split into 2-3 doses approximately 4-6 hours apart (e.g., 7 AM, 1 PM, 7 PM). Some users employ a "pulsing" strategy (e.g., 5 days on, 2 days off) to manage receptor desensitization and visual sides, though efficacy evidence is anecdotal. Dosing strategically around workouts may be beneficial.

    ●Visual Side Effect Management: The yellow tint usually appears within days of starting or increasing dose. If it becomes disruptive (affecting night driving, etc.), reducing the dose is necessary. The effect generally subsides within a few days of stopping S4. Never ignore significant vision changes.

    Cycles are typically shorter than some other SARMs due to the visual side effect and potential for receptor adaptation:

    ●Typical Duration: 6 to 8 weeks. Some push to 10-12 weeks at lower/moderate doses if sides are manageable, but longer cycles increase the risk of suppression and receptor desensitization.

    ●Stacking: S4 is often stacked with other compounds:

    ○With Ostarine (MK-2866): A popular "lean gains" or recomp stack, combining muscle building/preservation (Ostarine) with hardening/fat loss (S4). Doses are often moderate (e.g., Ostarine 20-25mg, S4 35-50mg).

    ○With Cardarine (GW-501516): Focuses intensely on fat loss, endurance, and vascularity. Cardarine is not a SARM (it's a PPARδ agonist) but complements S4's effects well.

    ○With Other SARMs (LGD-4033, RAD-140): For more significant mass gains, though this significantly increases the risk of suppression and side effects. Requires careful consideration and potentially stronger PCT.

    ●Solo Cycles: Effective for recomping or cutting, especially for those sensitive to suppression from stronger SARMs.

    S4 has a relatively short half-life, estimated between 4 to 6 hours. This has key practical implications:

    ●Frequent Dosing Required: To maintain stable blood levels and consistent receptor stimulation, dosing 2-3 times per day is necessary. A single daily dose will lead to significant peaks and troughs.

    ●Faster Clearance: Ceases working relatively quickly after the last dose. Visual side effects also clear relatively quickly (days).

    ●Timing Flexibility: Allows users to time doses strategically around workouts for potential acute performance benefits.

    Like virtually all SARMs, S4 suppresses the body's natural testosterone production (Hypothalamic-Pituitary-Testicular Axis - HPTA). The degree of suppression depends heavily on:

    ●Dosage: Higher doses = greater suppression.

    ●Cycle Length: Longer cycles = greater suppression.

    ●Individual Sensitivity: Varies significantly.

    ●Stacking: Stacking SARMs, especially stronger ones, dramatically increases suppression risk.

    Therefore, Post-Cycle Therapy (PCT) is strongly recommended after S4 cycles, particularly those exceeding 6 weeks or using moderate/high doses (50mg+). The goal of PCT is to restore natural hormone production as efficiently as possible.

    ●PCT Components:

    ○SERMs (Selective Estrogen Receptor Modulators): The cornerstone of SARM PCT.

    ◇Tamoxifen (Nolvadex): Often preferred for SARM PCT. Typical protocol: 20mg/day for 4 weeks. Sometimes 20mg/day for 2 weeks followed by 10mg/day for 2 weeks.

    ◇Clomiphene (Clomid): Also effective. Typical protocol: 25mg/day for 4 weeks. Can sometimes cause more mood-related sides than Tamoxifen.

    ○Natural Testosterone Boosters (Optional/Supportive): Ingredients like D-Aspartic Acid, Ashwagandha, Zinc, Vitamin D may provide marginal support but are NOT a replacement for SERMs after a suppressive cycle. Their primary value is post-PCT maintenance.

    ○Blood Work (Highly Recommended): The gold standard. Getting hormone panels (Total Testosterone, Free Testosterone, LH, FSH, Estradiol) done before the cycle (baseline), near the end of the cycle, and 4-6 weeks after PCT provides objective data on suppression levels and recovery efficacy. This guides PCT necessity and duration.

    ●PCT Timing: Start PCT approximately 3-5 days after the last S4 dose, leveraging its short half-life. A typical PCT duration is 4 weeks.

    ●Suppression Reality: Ignoring PCT after a suppressive cycle leads to prolonged low testosterone symptoms: fatigue, low libido, depression, loss of muscle mass, and difficulty recovering. PCT is an investment in long-term health and retaining gains.

    ●Research Chemical Status: S4 is not approved for human use by any major regulatory body (FDA, EMA, etc.). It is sold for "research purposes" only. Quality, purity, and dosage accuracy from suppliers are significant concerns. There is no regulatory oversight.

    ●Lack of Long-Term Safety Data: The long-term effects of SARM use in otherwise healthy individuals are completely unknown. Potential impacts on cardiovascular health, lipids (cholesterol), liver enzymes (though generally considered less hepatotoxic than oral steroids), and other systems remain understudied outside therapeutic contexts.

    ●Testosterone Suppression: As emphasized, suppression is a near certainty with effective doses and cycle lengths. PCT is crucial but doesn't guarantee a perfect recovery.

    ●Visual Side Effects: This is a unique and dose-limiting factor for S4. It can be unsettling and functionally impairing for some.

    ●Potential Androgenic Side Effects: While reduced, side effects like acne, hair shedding (in predisposed individuals), and mild virilization in women (voice changes, clitoral enlargement) are still possible, especially at higher doses.

    ●Legality and Anti-Doping: S4 is banned by the World Anti-Doping Agency (WADA) and most professional sports organizations. Its legal status varies by country but is often in a grey area.

Brand	STROMUSC
Trade names	Acetamidoxolutamide; Androxolutamide; GTx-007; S-4
CAS	401900-40-1
Molar mass	441.363
Formula	C19H18F3N3O6
Purity	Above 98%
Apprarance	25mg*100

 

 

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    Andarine S4 occupies a unique niche in the bodybuilding SARM landscape. Its partial agonism, tissue selectivity, potent fat-loss and hardening effects, and distinctive visual side effect make it a tool for specific goals, primarily cutting, recomping, and contest prep conditioning. Its short half-life necessitates frequent dosing, and its suppressive nature mandates responsible PCT planning based on individual response and ideally blood work.

However, it is paramount to approach S4 with caution. It is an unapproved research chemical with unknown long-term risks. The visual disturbance is a significant practical drawback. Quality control is a gamble. While offering a potentially improved side effect profile compared to traditional steroids, it is not without substantial risks, particularly concerning HPTA suppression. Thorough research, realistic expectations, meticulous attention to dosing and side effects, and a commitment to proper PCT are non-negotiable for anyone considering its use. The pursuit of physique enhancement must always be balanced against the imperative of long-term health.

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