STROMUSC Superior Quality Aicar 10mg For Bodybuilding CAS:3031-94-5

    What It Is: Beyond the "Exercise in a Pill" Label

    AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) exists in a strange space within the bodybuilding world. It is a nucleoside analog, a naturally occurring compound within human cells, yet the version used in bodybuilding is a synthetic, research-grade chemical . To understand its allure, you must first understand the biological switch it flips: AMP-activated protein kinase (AMPK). AMPK acts as the body's master metabolic regulator. When your muscles contract during intense exercise, cellular energy depletes, and AMPK activates to restore energy balance by increasing glucose uptake and fatty acid oxidation .

    What AICAR does is chemically mimic this state. When administered, it enters cells and is phosphorylated into ZMP, a compound that tricks the body into thinking ATP (energy) is low, even when it isn't. This pharmacological activation of AMPK triggers the same metabolic adaptations as endurance training-without the actual mechanical contraction of the muscle . Initially developed in the 1990s for cardioprotective and metabolic disorder research, AICAR gained notoriety in the bodybuilding underground following a landmark 2008 study by Ronald Evans' team at the Salk Institute. In that study, sedentary mice injected with AICAR ran 44% longer than untreated mice, coining the term "exercise in a pill" .

    For bodybuilders, superior quality AICAR (often referenced in 10mg dosages for injectable or oral reconstitution) is sought not for raw strength, but for its ability to alter muscle fiber composition, enhance fat oxidation, and potentially mimic the cardiovascular conditioning achieved through relentless cardio.

    The application of AICAR in bodybuilding diverges significantly from its use in endurance athletics. While marathon runners might use it for sheer aerobic capacity, bodybuilders utilize it for two specific applications: fat loss preservation and glycogen supercompensation.

    During cutting phases, bodybuilders often restrict carbohydrates to deplete glycogen. This state typically increases muscular fatigue and reduces training intensity. AICAR application here serves to increase GLUT-4 translocation (glucose transporters) and hexokinase activity, effectively allowing the muscle to utilize what little glucose remains more efficiently . A 2025 study on aged mice showed that AICAR treatment increased quadricep weight by approximately 8% and tetanic force production by 26.4% by improving mitochondrial markers like cytochrome C . For a bodybuilder in a caloric deficit, this translates to maintained muscle density and contractile force despite low energy availability.

    Secondly, AICAR is utilized in the days leading up to a photoshoot or competition. By activating AMPK, it drives a metabolic shift toward lipid utilization. It prevents the inhibition of fatty acid oxidation that usually occurs when insulin and glucose are elevated . This allows the user to consume carbohydrates for muscle fullness (glycogen loading) without blunting fat burning-a metabolic "trick" that helps achieve the dry, grainy look prized on stage.

    The benefits touted by proponents are rooted in the upregulation of PPARδ co-activators and mitochondrial biogenesis. When AMPK is chronically activated, the muscle undergoes a fiber-type shift. Type IIb (fast-twitch, glycolytic, fatigue-prone) fibers begin to express characteristics of Type I (slow-twitch, oxidative, fatigue-resistant) fibers . For a bodybuilder, this does not mean sacrificing size; rather, it means enhanced recovery between sets and the ability to maintain tension under heavy loads for longer durations.

    Furthermore, AICAR acts as a potent nutrient partitioner. By increasing AMPK, it inhibits acetyl-CoA carboxylase (ACC), an enzyme responsible for converting acetyl-CoA into malonyl-CoA. When ACC is inhibited, malonyl-CoA drops, which removes the brakes on carnitine palmitoyltransferase-1 (CPT-1). This allows fatty acids to flood the mitochondria for oxidation . The result is a direct reduction in intramuscular lipid accumulation, which can improve insulin sensitivity and vascularity.

    Recent research also highlights its role in reducing muscle wasting. AICAR has been shown to suppress the expression of muscle-specific ubiquitin ligases Mafbx and Murf1-genes that drive muscle atrophy . This anti-catabolic environment is highly desirable during aggressive cutting cycles where cortisol is elevated.

    Determining the dosage for AICAR is challenging due to the lack of human clinical trials for performance enhancement. However, extrapolation from animal models provides a framework. The seminal studies in mice used dosages ranging from 500 mg/kg/day to 1 mg/g of body weight . For a human, this dosage would be prohibitively expensive and potentially toxic. Bodybuilding protocols are therefore micro-dosed by comparison.

    For superior quality 10mg vials, a typical protocol involves:

    ●Dosage: 5mg to 10mg administered once daily.

    ●Administration: Subcutaneous injection (into abdominal fat) or intramuscular (into the deltoid or quadriceps) to maximize bioavailability.

    ●Cycle Length: 4 to 8 weeks.

    Unlike anabolic steroids, AICAR does not operate on a receptor saturation model; it works on enzymatic pathways. It is often pulsed. Some users employ a "loading phase" of 10mg per day for the first two weeks to saturate AMPK signaling, followed by a maintenance phase of 5mg per day. It is rarely used standalone; it is typically stacked with GW501516 (Cardarine) to synergistically activate both AMPK and PPARδ pathways, creating a potent endurance and fat-loss cocktail .

    The half-life of AICAR in plasma is notoriously short. Research indicates that while the acute activation of AMPK occurs within 30 to 60 minutes post-injection, the downstream transcriptional changes (mRNA expression) persist much longer . The compound itself has a half-life of roughly 30 to 60 minutes, but the phosphorylation of downstream targets can last for several hours.

    Given this short half-life, timing is everything. Most users administer AICAR immediately prior to fasted cardio or training. The rationale is that the artificial activation of AMPK synergizes with the natural AMPK rise from exercise, amplifying the signal for mitochondrial biogenesis and fat oxidation. Administering AICAR in a fed state (high insulin) may blunt its effectiveness, as insulin tends to suppress AMPK activity .

    This is where AICAR deviates entirely from anabolic steroid use. AICAR does not suppress the hypothalamic-pituitary-gonadal (HPG) axis; therefore, a traditional PCT involving SERMs like Nolvadex or Clomid is unnecessary and irrelevant for restoring testosterone. However, the concept of a "PCT" for AICAR focuses on metabolic recovery.

    Chronic AMPK activation can suppress the mTOR pathway, which is the primary driver of muscle protein synthesis. If a bodybuilder runs AICAR for too long, they risk creating a metabolic environment that favors oxidation over anabolism. Therefore, the "PCT" for AICAR involves:

    1.Cessation: Simply stopping the compound, allowing the natural AMPK feedback loops to reset.

    2.Nutritional Rebound: Increasing caloric intake, specifically carbohydrates, to stimulate insulin release. Insulin is a natural antagonist of AMPK. A higher insulin environment helps restore mTOR sensitivity and glycogen supercompensation.

    3.Supplemental Support: Utilizing supplements like L-carnitine and coenzyme Q10 to support the mitochondrial density that was built during the cycle, ensuring the adaptations are retained even after the drug is cleared.

    Because AICAR is not a hormone, no "crash" occurs upon cessation. Instead, the user may notice a slight decrease in cardiovascular endurance and a potential increase in appetite, as AMPK activation in the hypothalamus is known to stimulate hunger .

    It is impossible to discuss AICAR without addressing the elephant in the room: risk. The World Anti-Doping Agency (WADA) banned AICAR in 2009 under the class of Hormone and Metabolic Modulators . For a competitive bodybuilder, a positive test for AICAR results in significant sanctions.

    Beyond legality, the health risks are substantial. AICAR is not approved for human therapeutic use anywhere in the world . The 2024 news reports from Radboudumc highlight that AICAR never became a registered drug due to "many side effects" . Animal models show that excessive AMPK activation in non-target tissues can lead to neurodegeneration and potential cardiotoxicity. Furthermore, because AICAR works by altering glucose metabolism, there is a high risk of hypoglycemia. Users often report severe lethargy and "hypoglycemic shakes" if the dosage is too high or administered without adequate carbohydrate intake. There are also concerns regarding the accumulation of naturally occurring AICAR in the body being linked to metabolic disorders .

Brand	STROMUSC
Trade names	Aminoimidazole carboxamide ribonucleotide, AICA ribonucleotide, ZMP
CAS	3031-94-5
Molar mass	338.213
MF	C9H15N4O8P
Purity	Above 98%
Apprarance	10mg*100

 

 

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    Superior quality AICAR 10mg represents the cutting edge-and the extreme risk-of metabolic enhancement in bodybuilding. It is not a mass builder; it is a metabolic re-modeler. It offers the theoretical promise of enhanced fat oxidation, improved insulin sensitivity, and fatigue resistance that rivals natural endurance training. For the bodybuilder, it is a tool used in the final weeks of preparation to maintain muscle fullness while stripping away intermuscular fat.

 

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