Ostarine O-Acetate（OTR-AC） Sarms Powder For Bodybuilding CAS:1025658-44-9

     OTR-AC, also called Ostarine-O-Acetate, is MK-2866 (Ostarine) which has undergone esterification during chemical synthesis to maximize the potency, biodistribution, and half-life. The esterification of anabolic agents results in at least a 10-fold increase in half-life, which means that the active ingredient has the potential to remain bioactive ten times longer. Currently, OTR-AC is being researched to potentially prevent muscle wasting disease and increase muscle mass.

    Ostarine is a Selective Androgen Receptor Modulator (SARM). It is also known as enobosarm or Gtx-024. It is a non-steroidal substance that does not undergo aromatization and reduction by aromatase and 5- reductase which is typical of conventional anabolic compounds.

    To understand the mechanism of action of OTR-AC, we must first look into the workings of the selective androgen receptor modulators as a collective group of compounds.

    As the name implies, compounds that fall into the category of SARM have the ability to stimulate the androgen receptors in the body. Interestingly, these compounds partially mimic androgens by acting only on skeletal muscle tissue and therefore are a go-to choice for muscle building.

    Like androgens, OTR-AC enters the cytoplasm of a cell and binds to androgen receptors. Then it translocates to the nucleus where the androgen receptor's interaction with OTR-AC acts as a transcriptional regulator, which recruits cofactors and co-regulatory proteins.

    This action of acquiring only a specific kind of co-regulatory protein allows OTR-AC to regulate gene expressions and bring about a number of diverse changes in the body.

    The most important and well-recognized effect of OTR-AC is an increase in muscle growth. OTR-AC increases muscle fibers, capillary density, and muscle enzyme activity while simultaneously promoting the proliferation of muscle tissue.

    When muscle mass in the body increases, more energy is required for the functioning and repair of muscle cells. This energy is primarily derived from the breakdown of fat cells in the body, as a result of which the amount of fat stored in the body decline in people who are taking OTR-AC.

    By reducing body fat, OTR-AC also helps in lowering cholesterol levels, specifically low-density lipoprotein, which can have serious adverse effects on cardiac health. This is particularly seen in post-menopausal women who are at a greater risk of cardiac events.

    Some clinical trials have also concluded that subjects that were treated with OTR-AC showed a decrease in fasting blood glucose, insulin levels, and insulin resistance.

    Laboratory research done on ovariectomized rats found that OTR-AC had significant effects on bone healing. It improved callus formation and bone mineral density and also accelerated the time it took for osteotomy to heal. Similarly, it can also contribute to the rapid healing of skeletal muscles.

    Numerous animal and human studies have been conducted on the potential application of OTR-AC. Below follows some of the relevant findings:

    OTR-AC on Cancer Cachexia

    Cancer-induced muscle wasting begins early in a patient's malignant disease, resulting in decreased physical function and other negative clinical outcomes. The small sample size and diversity of cancer types studied could be viewed as potential limitations, despite the fact that this is the first study to demonstrate that a selective androgen receptor modulator increased lean body mass and improved physical function in cancer patients with pre-existing cachexia (muscle loss). 

    OTR-AC on Lean Body Mass

    In a study conducted on elderly men and postmenopausal women, GTx-024 improved total lean body mass and physical function in a dose-dependent manner and was well tolerated. GTx-024 could be used to prevent and/or treat muscle wasting caused by cancer and other chronic diseases.[R] Additional study is needed to demonstrate its efficacy.

    OTR-AC on Postmenopausal Osteoporosis

    In ovariectomized rats, Ostarine appeared to have a positive effect on early bone healing. Given its favorable effect on non-osteotomized bone and muscle, this treatment could be investigated further as an osteoporosis therapy. However, potential metabolic side effects should be considered first.

    In another study, Ostarine's short-term therapy of osteoporotic bone improves a number of microstructural bone parameters. Even though biomechanics have not changed, it is possible that a lengthier course of treatment could enhance biomechanical qualities. 

    Ostarine's longer-term effects and side effects in osteoporosis require further studies in rat models to eventually understand its safety for human consumption.

    OTR-AC on Improvement of Muscle Tissue

    Ostarine is a compound that has recently gained popularity as a result of its potential health benefits. It's a selective androgen receptor modulator (SARM) that has been studied in laboratory research for its ability to improve physical performance and muscle growth. A rat study was done in Sprague-Dawley rats and was able to conclude that Ostarine increased muscle vascularization by increasing capillary density and increasing muscle enzyme activity while having no hypertrophic effect on muscle fibers. 

    In another study, rats with increased myogenin, MyoD, and MyH expression after receiving Ostarine for 30 days also have more muscle mass. The investigation leads to the conclusion that Ostarine activates the androgen receptor to promote the proliferation and differentiation of muscle tissue.

    More research is needed for higher dosages because they can cause unfavorable side effects and may limit their application at these dosages.

    OTR-AC on Diabetes

    Subjects treated with Ostarine had shown a decrease in fasting blood glucose, a decrease in insulin levels, and a decrease in insulin resistance (homeostasis model assessment), implying that SARMs may have therapeutic potential in diabetics or people at risk for diabetes. 

    To better comprehend its mechanical function and value, more research is necessary

    OTR-AC on Cholesterol

    In the same study, OstarineTM caused a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio remaining in the low cardiovascular risk category for all doses. [R] Since there are few studies available, more research is required to demonstrate its effectiveness.

    OTR-AC Research may Stack well with:

    Ligandrol (LGD-4033) 

    MK 677 (Ibutamoren)

    RAD 140 (Testolone)

    The AC MK 2866 ester is frequently researched alongside these compounds due to the potential chemical synthesis they have together, though more research is required.

    OTR-AC Effects 

    Potential to aid the prevention of muscle wasting

    Potential to improve lean body mass

    Potential applications in insulin resistance

    Potential to reduce liver damage

    Is OTR-AC Illegal to Purchase?
    OTR-AC is legal to purchase as a research compound.

    Like other selective androgen receptor modulators, it can be used for laboratory research use only. However, since it is on the World Anti-Doping Agency's list, athletes and professionals should avoid this compound.

    OTR-AC has demonstrated its ability to improve lean muscle mass, reduce body fat and increase bone mineral density in a clinical study. More long-term randomized clinical trials are needed to understand its safety and efficacy in humans.

Product Name	OTR-AC,Ostarine O-Acetate
CAS	1025658-44-9
Molar mass	431.37
MF	C21H16F3N3O4
Purity	Above 98%
Apprarance	White Cyrstalline Powder

 

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    Ostarine O-Acetate, also known as Enobosarm, is a selective androgen receptor modulator (SARM). SARMs like Ostarine are compounds that selectively target androgen receptors in the body, aiming to elicit similar effects to those of anabolic steroids while potentially reducing some of the unwanted side effects associated with traditional steroids.

    As for Ostarine O-Acetate specifically, information might be limited, as it might refer to a particular chemical variation or formulation of Ostarine. Ostarine itself (Enobosarm) has been studied for various potential applications, but it's important to note that its use has not been approved for medical purposes in many countries, including the United States.

    SARMs like Ostarine have been researched for potential uses in:

    ●Muscle Wasting: Research suggests that Ostarine may have the potential to prevent muscle wasting and promote muscle growth, making it of interest in conditions where muscle loss occurs, such as in certain diseases or during aging.

    ●Osteoporosis: Some studies have explored the effects of SARMs, including Ostarine, on bone density and strength, indicating potential applications in conditions like osteoporosis.

    ●Hormone Replacement Therapy: SARMs have been investigated as potential alternatives for hormone replacement therapy in conditions where anabolic effects are desired without the androgenic side effects commonly associated with traditional anabolic steroids.

    It's important to emphasize that while SARMs like Ostarine may have shown promise in research, their safety, long-term effects, and potential side effects in humans are not fully understood. Furthermore, the use of SARMs for purposes such as athletic performance enhancement or bodybuilding is not approved and may carry risks.

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