Superior Quality AC-262536 Powder For Bodybuilding CAS:870888-46-3

   What It Actually Is

    Let me cut through the marketing noise right away. AC-262536 is not your run-of-the-mill SARM. Its full chemical name reads like a tongue-twister-4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile-and the molecular formula sits at C18H18N2O with a molecular weight of 278.36. But the numbers that actually matter are far smaller.

    This compound binds to the androgen receptor with a Ki of 5.01 nanomolar and triggers partial agonist activity at an EC50 of just 1.58 nanomolar in luciferase assays. For those not steeped in pharmacology jargon, that means it latches onto the receptor with remarkable precision and activates it in a controlled, dialed-down way-unlike full agonists that often go pedal-to-the-metal.

    Here is what separates AC-262536 from the pack: it demonstrates selectivity for the androgen receptor across a panel of 47 other human nuclear receptors at 10 micromolar concentrations. That degree of specificity is rare in the research chemical world and explains why this compound has drawn serious scientific attention since its first publication in 2008.

    The chemical structure places it firmly in the naphthalene class-two fused benzene rings that give it its backbone. But unlike the steroidal architecture of traditional androgens, AC-262536 is completely non-steroidal. This is the fundamental design shift that enables its tissue-selective behavior. Traditional anabolic steroids cannot discriminate where they exert their effects; AC-262536 was engineered from the ground up to do exactly that.

    Understanding how AC-262536 works requires stepping back and looking at why traditional androgens fail. Testosterone replacement therapy, for all its benefits, carries baggage: cardiovascular risks, lipid disturbances, hepatotoxicity, gynecomastia, and the ever-present concern about prostate stimulation. Oral testosterone formulations come with documented liver toxicity, including the potential for neoplasms. And crucially, testosterone cannot differentiate between anabolic effects on muscle and androgenic effects on tissues like the prostate and skin.

    AC-262536 solves this problem through a concept called partial agonism. Unlike testosterone, which acts as a full agonist-meaning it maximally activates the androgen receptor wherever it binds-AC-262536 only partially activates the receptor. Think of it like a dimmer switch versus an on-off switch. This partial activation profile allows the compound to trigger anabolic signaling in muscle tissue while producing only muted androgenic effects elsewhere.

    The animal data backs this up convincingly. In a two-week chronic study conducted on castrated male rats-animals essentially devoid of endogenous androgens-AC-262536 significantly stimulated levator ani muscle growth while leaving prostate and seminal vesicle weights relatively unchanged. Testosterone, by sharp contrast, bulked up both muscle and prostate tissue indiscriminately. The levator ani muscle is the standard preclinical marker for anabolic activity; the prostate and seminal vesicles serve as the benchmarks for androgenic side effects. AC-262536 passed this test with flying colors.

    The compound also demonstrated the ability to suppress elevated luteinizing hormone levels in castrated rats, acting through classic negative feedback on the hypothalamic-pituitary-gonadal axis-but with a lighter touch than full androgens. At 3 mg/kg doses, LH levels dropped by roughly 40 percent, with an ED50 of 2.8 mg/kg. At the 10 and 30 mg/kg doses, the suppression effects actually exceeded those of testosterone propionate, suggesting that partial agonism does not equate to weak activity.

    One more layer worth noting: AC-262536 dose-dependently inhibits dihydrotestosterone-induced proliferation of LNCaP prostate cancer cells, with 47 percent inhibition at 100 nanomolar and about 51 percent at 1 micromolar. This suggests the compound may act as a functional antagonist in prostate tissue-exactly the opposite of what you would expect from traditional androgens. That is a remarkable pharmacological trick.

    When discussing superior quality AC-262536 powder, several physical and chemical parameters distinguish premium material from diluted or degraded product. The pure compound appears as a white to off-white solid powder with a melting point that remains consistent under proper storage conditions. Its LogP value sits at approximately 3.268, indicating moderate lipophilicity that supports oral bioavailability.

    Storage requirements matter enormously. The powder maintains stability for up to three years when kept at minus 20 degrees Celsius, and for two years at 4 degrees Celsius. Once dissolved in solvent, the timeline shortens considerably: six months at minus 80 degrees, one month at minus 20 degrees. Superior quality powder arrives in sealed, moisture-proof containers, shipped under appropriate temperature controls-typically blue ice for evaluation samples, room temperature for bulk quantities when transit times remain short.

    Solubility presents one practical consideration. AC-262536 dissolves at 25 milligrams per milliliter in DMSO, but requires ultrasonic treatment and warming to 60 degrees Celsius to achieve full dissolution. This is not a compound that simply stirs into solution. The powder can also be formulated into PEG-400 suspensions for research purposes, though DMSO remains the preferred solvent for precise volumetric dosing.

    Purity claims from reputable suppliers consistently exceed 98 percent, with many listing 99.94 percent purity specifications. The difference between a 98 percent product and a 99.94 percent product may seem negligible, but in research chemicals, those remaining percentages determine the presence of synthesis byproducts, unreacted intermediates, or degradation compounds that could influence biological outcomes.

    The legitimate research applications of AC-262536 span several domains. The compound has been studied for potential use in muscle wasting conditions, osteoporosis, and androgen receptor pharmacology in both cellular and animal models. The growth-promoting and bone-supporting effects documented in preclinical research make it relevant to conditions involving age-related functional decline or disease-induced muscle loss.

    In the bodybuilding community, AC-262536 has gained attention for a specific reason: its ability to promote anabolic effects without the androgenic baggage that accompanies traditional compounds. The partial agonist profile means users typically report noticeable improvements in muscle hardness, recovery capacity, and lean tissue retention without the aggressive water retention, acne, or hair loss commonly associated with full androgens.

    What makes AC-262536 particularly interesting is its lack of aromatization into estrogenic metabolites. Because it does not convert to estrogen, the typical side effects of estrogenic activity-gynecomastia, water bloat, blood pressure elevation-remain absent from the equation. This also eliminates the need for aromatase inhibitors, selective estrogen receptor modulators, or other ancillary medications that often accompany steroid cycles.

    The compound also appears to have minimal impact on liver enzymes at reasonable doses, distinguishing it from oral steroids like Anadrol or Dianabol, which carry well-documented hepatotoxicity concerns. Cardiovascular markers, including lipid profiles, show less disturbance compared to traditional androgens, though systematic human data remains limited.

    Here is where things get frustrating for anyone seeking clear answers. DrugBank lists the half-life as simply "Not Available," reflecting the fact that formal pharmacokinetic studies in humans have not been published. Researchers and experienced users have had to reverse-engineer practical half-life estimates from rodent data and real-world usage patterns.

    Rodent studies administered AC-262536 subcutaneously at doses of 3, 10, and 30 milligrams per kilogram daily for 14 consecutive days. Translating these doses to humans using standard allometric scaling suggests research doses in the range of 0.5 to 5 milligrams per kilogram per day. In practical terms, this has translated into user-reported dosages between 10 and 50 milligrams daily, with many finding the sweet spot somewhere in the 20 to 30 milligram range.

    The compound is typically dosed once daily due to the expected duration of action. Based on its binding affinity and partial agonist characteristics, the elimination half-life is likely in the range of 12 to 24 hours-enough to maintain relatively stable plasma levels with once-daily administration, though individual metabolism certainly plays a role.

    Cycle lengths vary by goal. Short cycles of four to six weeks are common for first-time users seeking to assess tolerance and response. Standard cycles typically run eight to ten weeks. Extended cycles beyond twelve weeks are rarely recommended, as the cumulative suppression of the HPTA axis becomes more pronounced with longer exposure times.

    One unique aspect of AC-262536 cycle design is the possibility of combining it with other non-androgenic compounds. Unlike full androgens that often require stacking with multiple ancillaries, AC-262536 pairs relatively cleanly with compounds like MK-677 (ibutamoren) for growth hormone pathway enhancement or cardarine (GW-501516) for endurance and lipid benefits. Stacking with other SARMs is generally discouraged, as receptor competition may blunt the effects of each individual compound.

    A persistent myth circulates that certain SARMs require no post-cycle therapy because they produce no suppression. This is incorrect for essentially every SARM, including AC-262536. The compound reduces plasma luteinizing hormone levels in castrated rats-animals with no endogenous testosterone production-demonstrating clear feedback on the HPTA axis. If it suppresses LH in a castrated model, it will suppress LH in humans with functioning testes.

    The degree of suppression appears milder than that of full androgens or more aggressive SARMs like RAD-140 or LGD-4033. But mild suppression is still suppression. Users typically report that natural testosterone levels recover to baseline within four to six weeks without pharmaceutical intervention, assuming a cycle of moderate duration and dosage.

    That said, evidence-based practice supports having a PCT protocol ready. Standard approaches include selective estrogen receptor modulators like tamoxifen or enclomiphene, typically run at 20 to 40 milligrams daily for two to four weeks post-cycle. Blood work before, during, and after any research chemical cycle is the only reliable way to determine whether PCT is actually necessary for any given individual.

    The good news: because AC-262536 does not aromatize to estrogen, the typical estrogen rebound that complicates PCT after steroid cycles does not occur. This simplifies the recovery process considerably. No need for aromatase inhibitors, no risk of estrogenic side effects during the washout period.

Trade names	AC-262,536
CAS	870888-46-3
Molar mass	278.355
MF	C18H18N2O
Purity	Above 98%
Apprarance	White Cyrstalline Powder

 

 

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    Superior quality AC-262536 powder represents one of the more intriguing developments in selective androgen receptor modulation. Its partial agonist profile, tissue selectivity, and lack of estrogenic activity set it apart from both traditional androgens and many other SARMs on the market. The animal data is solid. The pharmacological rationale is sound. The practical applications for bodybuilding revolve around lean tissue accrual without the side effect burden of traditional compounds.

    For those proceeding regardless, the principles remain the same as with any research compound: start with low doses, monitor physiological responses, obtain baseline and follow-up blood work, plan for PCT, and understand that the long-term consequences remain genuinely unknown. AC-262536 is a powerful research tool with legitimate potential, but like any tool, its value depends entirely on how it is used-and whether the user understands what they are actually handling.

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