Superior Quality RAD140(Testolone)Powder For Bodybuilding CAS:1182367-47-0

   What Exactly Is RAD140?

    RAD140 belongs to a class of molecules called Selective Androgen Receptor Modulators. The original patent work came from Radius Health, with preclinical characterization published back in 2010. Its IUPAC name is a mouthful: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile.

    Here is what actually matters: RAD140 binds to the androgen receptor with a Ki value of 7 nanomolar. In plain language, that means it grabs onto the receptor extremely tightly. Compare that to natural testosterone, and you start to understand why experienced users describe RAD140 as feeling distinctly different from other SARMs-denser, harder, more aggressive.

    The defining feature of RAD140 is its tissue selectivity. In castrated male rat models, researchers found that RAD140 at 0.03–0.3 mg/kg stimulated muscle weight gain without affecting the prostate or seminal vesicles. At higher doses (0.3–1 mg/kg), partial antagonist activity appeared in those tissues. That selectivity is the entire point of SARMs: building muscle without blowing up the prostate or triggering the androgenic side effects that come with traditional anabolic steroids.

    RAD140 is not subtle. Users report rapid gains in dry, hard mass-the kind of muscle that looks dense and vascular rather than puffy and waterlogged. Strength increases are dramatic, often appearing within the first two weeks of administration. Recovery between workouts shortens noticeably. Stamina climbs.

    What separates RAD140 from many other SARMs is its effect on body composition. While the compound does not directly stimulate lipolysis, the metabolic environment it creates-higher basal metabolic rate driven by lean mass accrual-pushes the body toward recomposition. Users frequently report losing body fat while simultaneously gaining muscle, something most traditional cutting agents cannot deliver without sacrificing tissue.

    Anecdotally, experienced lifters describe the RAD140 look as "hardening" of the muscle. Estrogen does not spike on this compound. Some users even report decreased estrogen levels, which contributes to the dry, grainy appearance. This makes RAD140 particularly attractive for bodybuilders in contest prep or anyone chasing that lean, shredded aesthetic.

    Not all RAD140 powder is created equal. Research-grade material typically specifies purity ≥98%, with some suppliers offering ≥99% purity verified by HPLC.

    When assessing powder quality, third-party independent lab testing is the only real standard. Legitimate suppliers provide certificates of analysis that are current and verifiable. Any source unwilling to show you these documents should be avoided outright.

    The powder itself appears as an off-white to white crystalline solid. Proper storage matters enormously: the lyophilized powder should be kept at -20°C, where it remains stable for up to three years. Once dissolved in solution, stability drops to six months at -20°C. Multiple freeze-thaw cycles degrade the compound, so aliquoting is the smart play.

    RAD140 is orally bioavailable, which eliminates needles from the equation. A single daily dose is sufficient-splitting is unnecessary. Most users take it either first thing in the morning or approximately one hour before training.

    The standard cycle length runs eight weeks, followed by a break of at least five weeks. For those running higher doses, an eight-week off-period is recommended.

    Dosing is where personal response varies widely. Common cycles range from 10 mg to 30 mg per day. Many users start at 10–15 mg for the first two weeks to assess tolerance, then ramp up to 20 mg. Some experienced individuals push to 30 mg, but side effects escalate significantly beyond that threshold.

    Advanced users in contest prep sometimes run shorter cycles at higher doses-six weeks at 20–30 mg is common. Ten-week cycles exist but are considered advanced territory with proportionally greater suppression and recovery challenges.

    The pharmacokinetic data is clarifying. The elimination half-life of vosilasarm (RAD140) is 45 to 60 hours. This is considerably longer than the 16-hour figure that circulated in early anecdotal reports. The clinical data now available suggests a once-daily dosing schedule is entirely appropriate-twice-daily administration is unnecessary.

    A half-life in this range means RAD140 reaches steady-state plasma concentrations in approximately 7 to 10 days. It also means the compound lingers in the system for a considerable period after the last dose, which has implications for post-cycle therapy timing.

    RAD140 is suppressive. This is not negotiable. The compound strongly downregulates the hypothalamic-pituitary-gonadal axis, which means natural testosterone production drops during the cycle.

    Users report that the degree of suppression correlates directly with dose and cycle length. At 10–15 mg, many experience manageable lethargy toward the end of an eight-week run. At 20–30 mg, the fatigue becomes more pronounced. Some describe a crushing lethargy after week four that makes daily functioning difficult without a testosterone base.

    The mechanism is worth understanding: RAD140 does not completely shut down LH and FSH the way exogenous testosterone does. LH and FSH remain partially functional, which is why recovery is generally faster than coming off a full steroid cycle. But make no mistake-total testosterone will be significantly suppressed by the end of eight weeks.

    PCT is mandatory after any meaningful RAD140 cycle. The standard approach is to wait 2–3 days after the last dose before beginning PCT, accounting for the long half-life and allowing some clearance.

    A typical SERM-based PCT runs four weeks. Nolvadex at 40/40/20/20 mg per day is the conventional protocol. Clomid at 50/50/25/25 mg is also used. Some users run a "mini PCT" with half-doses, but this is only appropriate for shorter cycles or lower doses.

    Blood work before and after the cycle is the only reliable way to confirm full recovery. Guessing leaves you vulnerable to prolonged hypogonadism, which brings its own cascade of problems-low libido, depression, fatigue, and metabolic dysfunction.

    The risk picture for RAD140 has become clearer with recent case reports. A 2025 publication documented cholestatic drug-induced liver injury from RAD-140 that required corticosteroid treatment. This follows earlier reports linking SARMs, including RAD140, to liver toxicity and myocarditis.

    Other reported side effects include:

    ●Testosterone suppression with corresponding symptoms: decreased libido, fatigue, mood changes

    ●Androgenic effects at higher doses: acne, oily skin, accelerated hair loss in predisposed individuals

    ●Lipid profile disturbances: adverse effects on HDL and LDL cholesterol, increasing cardiovascular risk

Trade names	RAD140; RAD-140; EP0062; testolone,Vosilasarm
CAS	1182367-47-0
Molar mass	393.83
MF	C20H16ClN5O2
Purity	Above 98%
Apprarance	White crystal powder

 

 

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    RAD140 delivers what it promises: serious muscle accrual, strength that climbs week after week, and a dry, hard physique that looks like contest condition. But potency comes with a price tag that includes suppression, potential liver stress, and the logistical burden of proper PCT.

    For those willing to manage the risks, track blood work, and respect the compound, RAD140 remains one of the most effective tools in the research chemical space. For everyone else-there are safer roads to walk.

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