High-Quality STROMUSC Methyltrienolone(Metribolone)5mg/ml For Bodybuilding CAS:965-93-5

   What Is Methyltrienolone?

    Chemical Identity and Origins

    Methyltrienolone-systematically designated as 17α-methylestra-4,9,11-trien-17β-ol-3-one-is a synthetic anabolic-androgenic steroid belonging to the 19-nortestosterone (nandrolone) family. Its developmental code, R1881, reflects its origins in the research laboratories of Roussel-UCLAF during the 1960s, where it was investigated as a potential therapeutic agent. What researchers discovered was a compound of such staggering potency and such profound hepatotoxicity that commercialization was abandoned before it ever began.

    Structural Uniqueness

    The molecular architecture of Methyltrienolone is deceptively simple yet pharmacologically devastating. It is, at its core, trenbolone that has undergone 17α-alkylation-the addition of a methyl group at the 17-alpha position. This seemingly minor modification accomplishes something remarkable: it renders the compound orally bioavailable by protecting it from first-pass hepatic metabolism. Without this alkylation, trenbolone-already one of the most potent injectable androgens known-would be destroyed by the liver before it could exert systemic effects.

    The molecule features a distinctive triene structure-three conjugated double bonds within the steroid backbone-that contributes to its extraordinary receptor-binding affinity. This triple bond configuration, combined with the 17α-methyl group, creates a compound that binds to the androgen receptor with a Ki value of approximately 0.09 nM, making it one of the tightest-binding androgens ever synthesized.

    A Note on the 5mg/mL Concentration

    The 5mg/mL formulation represents a concentrated solution typically encountered in research or underground laboratory preparations. At this concentration, each milliliter contains five milligrams of active compound-a figure that sounds modest until one appreciates that effective dosages are measured not in milligrams but in micrograms. A single milliliter of 5mg/mL solution contains enough Methyltrienolone for approximately ten to twenty individual doses, underscoring the extraordinary potency of this substance.

    Androgenic and Anabolic Potency

    The potency figures associated with Methyltrienolone border on the absurd. According to Julius Vida's comprehensive work "Androgens and Anabolic Agents: Chemistry and Pharmacology," 17α-methyltrienolone is listed at 30,000 times more anabolic than methyltestosterone. The anabolic-to-androgenic ratio is estimated at approximately 12,000:6,000-figures that render testosterone's 100:100 ratio almost comically feeble by comparison.

    Research in castrated male rats demonstrated that Methyltrienolone possesses 120 to 300 times the oral anabolic potency and 60 to 70 times the androgenic potency of the reference compound methyltestosterone. To put this in practical terms: one milligram of Methyltrienolone produces effects roughly equivalent to 100 milligrams of testosterone.

    Non-Aromatizing Nature

    Like its parent compound trenbolone, Methyltrienolone does not aromatize into estrogen. This means users need not concern themselves with estrogenic side effects such as water retention, gynecomastia, or the characteristic "puffiness" associated with aromatizable compounds. The dryness and hardness that result from this non-aromatizing profile make it particularly attractive during cutting phases or when a "grainy" aesthetic is the goal.

    However, the absence of estrogenic activity does not equate to an absence of side effects. As a 19-nor compound, Methyltrienolone carries progestogenic activity and has a demonstrated tendency to elevate prolactin levels. This prolactin elevation can, in susceptible individuals, lead to gynecomastia of a non-estrogenic variety-a complication that requires management with dopamine agonists such as cabergoline rather than aromatase inhibitors.

    Androgen Receptor Affinity

    Methyltrienolone binds to the androgen receptor with such extraordinary affinity that it has been employed in scientific research as a photoaffinity label for the androgen receptor. Its binding affinity surpasses that of dihydrotestosterone (DHT) and even trenbolone itself. This extreme receptor affinity translates into potent activation of androgen-dependent anabolic mechanisms, including enhanced protein synthesis and nitrogen retention.

Perhaps equally significant is the compound's remarkably low affinity for sex hormone-binding globulin (SHBG), estimated at less than 5% of that of testosterone. This means a greater proportion of the administered dose remains in its free, biologically active form, contributing to its extraordinary potency on a per-milligram basis.

    Anti-Catabolic Properties

    Methyltrienolone binds not only to androgen receptors but also to glucocorticoid receptors, where it acts as a potent antagonist. This glucocorticoid receptor antagonism translates into powerful anti-catabolic effects-the compound actively inhibits the muscle-wasting actions of cortisol. For bodybuilders operating in caloric deficits during cutting phases, this property is invaluable, as it helps preserve hard-won muscle tissue even under conditions that would otherwise promote catabolism.

    Bulking Applications

    For the bodybuilder seeking to add mass during a bulking phase, Methyltrienolone offers unprecedented anabolic stimulus. Users consistently report rapid increases in muscle fullness and density, often noticeable within the first week of administration. One documented user gained 15 pounds in three weeks while using the compound. The extreme androgen receptor stimulation drives protein synthesis to levels that conventional compounds simply cannot match, resulting in rapid accrual of lean tissue.

    Cutting and Recomposition

    Paradoxically, the same properties that make Methyltrienolone effective for bulking also make it exceptional for cutting. The non-aromatizing, non-estrogenic profile promotes a dry, hard appearance with visible vascularity and striations. The lipolytic effect stimulated by androgen receptor activation in adipose tissue promotes fat oxidation. Simultaneously, the anti-catabolic glucocorticoid antagonism protects muscle mass during caloric restriction. This combination of fat loss and muscle preservation-recomposition-is where Methyltrienolone truly distinguishes itself.

    Users describe the visual changes as occurring on a weekly, if not shorter, basis. The compound seems to fundamentally alter the body's partitioning of nutrients, directing resources toward muscle tissue while simultaneously mobilizing stored fat for energy.

    Strength Enhancement

    Perhaps the most immediately noticeable effect of Methyltrienolone is the dramatic increase in strength. Users report entering what has been described as "Freight Train Mode" within 45 minutes of administration. One experienced lifter reported that after a layoff of approximately two months, his first squat session back was troubled by 220 kilograms; within three weeks on Methyltrienolone, he was back over 300 kilograms raw. Another user documented a 50-kilogram increase in deadlift personal best within weeks.

    The strength increases are accompanied by notable aggression and focus-a "psychoactive" component that drives intensity in the gym. This aggression is not the chaotic, uncontrolled rage associated with some compounds but rather a focused, channeled intensity that allows users to push past previous limits.

    Rapid Onset of Action

    One of Methyltrienolone's most distinctive features is its extraordinarily rapid onset. Users report feeling effects as quickly as 15 minutes after administration, with peak effects typically manifesting within 45 minutes to 1.5 hours. This rapid onset makes it uniquely suited for use as a pre-workout compound-a role for which it has gained considerable popularity. The immediate availability of the compound allows users to time administration precisely to coincide with training sessions, maximizing the window of enhanced performance.

    Liver-Sparing Injectable Option

    While oral Methyltrienolone is notorious for its hepatotoxicity, the injectable formulation-prepared in oil and administered intramuscularly or subcutaneously-bypasses first-pass hepatic metabolism. This route of administration significantly reduces the direct toxic load on the liver, though it does not eliminate hepatic concerns entirely. Users who have experienced the oral version describe the injectable form as substantially more tolerable, with one noting that the injectable route "won't be as harsh on the liver sides".

    The injectable preparation at 5mg/mL contains such a small quantity of active compound per milliliter that the carrier oil constitutes the overwhelming majority of the injection volume. This results in virtually no post-injection pain, as the hormone concentration is too low to cause significant local irritation.

    Synergistic Stacking Potential

    Methyltrienolone stacks exceptionally well with other compounds. Users have successfully combined it with Superdrol, Anadrol, Winstrol, and Anavar. The compound's non-aromatizing nature means it can be added to virtually any stack without complicating estrogen management. However, the extreme hepatotoxicity of the oral version demands caution when stacking with other 17α-alkylated orals, as the cumulative liver stress can become dangerous.

    The Microgram Paradigm

    With Methyltrienolone, dosage is measured not in milligrams but in micrograms-a paradigm shift that many users find difficult to internalize. The effective dosage range for male users is generally 400 to 800 micrograms per day. Some experienced users report satisfactory results at doses as low as 250-500 micrograms. A small number of advanced users have pushed dosages to 1,000 micrograms (1mg) or even 1.5mg, though such doses are considered extreme and carry substantially elevated risk.

    Starting Protocol

    Given the compound's extreme potency and the significant individual variation in response, the prudent approach is to start low and titrate upward. A conservative starting dose of 250 micrograms allows the user to assess tolerance and response before considering escalation. If well-tolerated, the dose can be increased incrementally to 500 micrograms, then to 750 micrograms, and ultimately to 1,000 micrograms if the user's risk tolerance and goals justify it.

    The 5mg/mL Formulation

    For the 5mg/mL concentration, precision in measurement is absolutely critical. At this concentration:

    ●0.1 mL = 500 micrograms

    ●0.05 mL = 250 micrograms

    ●0.02 mL = 100 micrograms

    Given these minute volumes, accurate measurement requires a high-quality insulin syringe or micro-syringe with appropriate graduations. Errors in measurement can result in significant overdosing, with potentially serious consequences.

    Female Use

    Females are categorically not recommended to use this compound. The extreme androgenic potency-60 to 70 times that of methyltestosterone-virtually guarantees virilization effects including voice deepening, clitoral enlargement, facial hair growth, and irreversible masculinization. The risk-to-benefit ratio for female users is so unfavorable that responsible discussion of female dosing is essentially moot.

    Duration

    The consensus among experienced users is that Methyltrienolone cycles should be limited to four weeks or less. Some users restrict usage to even shorter periods, given the compound's extreme hepatotoxicity. The oral version, in particular, is so liver-toxic that extending beyond four weeks is considered imprudent regardless of liver support supplementation. One user succinctly summarized the risk: "This stuff is dangerous".

    Cycle Structure

    A typical Methyltrienolone cycle might be structured as follows:

    Weeks 1-4:

    ●Methyltrienolone: 500-750 mcg daily, divided into two doses

    ●Testosterone base (e.g., Testosterone Enanthate): 300-500 mg weekly

    ●Liver support: TUDCA 1g daily, NAC, milk thistle

    Optional additions:

    ●Masteron: 400 mg weekly (to complement the dry, hard aesthetic)

    ●Cabergoline: 0.5 mg twice weekly (if prolactin elevation occurs)

    Pre-Workout Application

    Due to its short half-life and rapid onset, many users employ Methyltrienolone as a pre-workout tool rather than as a continuous daily compound. In this application, a dose of 250-500 micrograms is administered approximately 45-60 minutes before training. This approach maximizes the acute performance-enhancing effects while minimizing cumulative exposure and associated toxicity.

    Stacking Considerations

    When stacking Methyltrienolone with other compounds, the following principles apply:

    Testosterone: A testosterone base is universally recommended. Running Methyltrienolone without exogenous testosterone is problematic because the compound suppresses natural production so effectively and rapidly that users experience symptoms of androgen deficiency. One user noted: "You'll probably see more sides running it alone than if you ran it with test".

    Other Orals: Extreme caution is required when stacking with other 17α-alkylated orals. The cumulative hepatotoxic load can become dangerous rapidly. One expert likened the toxicity of Methyltrienolone to "taking high dosages of Anadrol combined with high dosages of Halotestin concurrently".

19-Nors: When combined with other 19-nor compounds (trenbolone, nandrolone), prolactin elevation becomes a significant concern. Cabergoline or pramipexole should be available for management.

    Pharmacokinetics

    The half-life of oral Methyltrienolone is approximately 4 to 6 hours. This short duration means that blood levels decline rapidly after administration. For continuous exposure throughout the day, multiple daily doses are required-typically two doses spaced approximately 8-12 hours apart.

    Dosing Frequency

    For those running Methyltrienolone as a continuous daily compound, the standard approach is divided dosing-typically half the daily total administered in the morning and half in the evening. This divided schedule maintains more stable blood levels and reduces the amplitude of peak concentrations, potentially mitigating side effects.

    For pre-workout application, a single dose administered 45-60 minutes before training is sufficient. The rapid onset and short duration make it ideal for this purpose, as the compound's effects are concentrated precisely when they are most needed.

    Injectable Half-Life

    The injectable formulation, administered intramuscularly or subcutaneously, appears to have a somewhat prolonged effect compared to the oral version. Subcutaneous injection results in a slower absorption profile, a delayed onset, and potentially extended duration of action. This makes the injectable route more suitable for those seeking sustained effects throughout the day.

    The Suppression Reality

    Methyltrienolone suppresses natural testosterone production profoundly and rapidly. As a 19-nor compound with extreme androgen receptor affinity, it signals the hypothalamic-pituitary-gonadal axis to cease endogenous testosterone production almost immediately upon administration. Recovery from this suppression is not guaranteed and requires aggressive intervention.

    PCT Timing

    Because Methyltrienolone has a short half-life, PCT can be initiated 12-24 hours after the last dose. This rapid clearance means users do not need to wait the extended periods required for long-ester compounds. However, if Methyltrienolone is stacked with long-ester injectables (e.g., testosterone enanthate), PCT timing must account for the clearance of those compounds as well.

    PCT Protocol

    The severity of suppression induced by Methyltrienolone demands an aggressive PCT protocol. A comprehensive approach includes:

    Week 1-2:

    ●hCG: 500-1000 IU every other day (to stimulate testicular function)

    ●Clomid: 50 mg daily

    ●Nolvadex: 40 mg daily

    Week 3-4:

    ●Clomid: 25 mg daily

    ●Nolvadex: 20 mg daily

    Week 5-6:

    ●Clomid: 12.5 mg daily (optional taper)

    Ancillary Support

    Throughout PCT, liver support (TUDCA, NAC, milk thistle) should be continued. Given the hepatotoxic load imposed by Methyltrienolone, liver values may remain elevated for some time after cessation, and continued support is prudent. Additionally, natural testosterone boosters may be employed, though their efficacy in the context of severe suppression is limited.

    ecovery Expectations

    Full recovery of the HPTA axis after a Methyltrienolone cycle is not guaranteed. The profound suppression induced by this compound can, in some cases, result in persistent hypogonadism requiring testosterone replacement therapy. Users should enter a Methyltrienolone cycle with full awareness that their natural testosterone production may never fully recover.

Brand	STROMUSC
Trade names	Methyltrienolone, 17α-Methyltrenbolone; R1881; R-1881; RU-1881; NSC-92858; 17α-Methyl-19-nor-Δ9,11-testosterone; 17α-Methylestra-4,9,11-trien-17β-ol-3-one
CAS	965-93-5
Molar mass	284.399
Formula	C19H24O2
Purity	Above 98%
Apprarance	5mg/ml, 10ml/bottle

 

 

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    Methyltrienolone is not a compound for beginners, nor is it a compound for the faint of heart. It is a tool for the most advanced bodybuilders-those who have exhausted conventional pathways and understand the risks they are accepting. One forum user summarized the sentiment succinctly: "The reality is that doing a Metribolone cycle is a terrible idea, but there's still room for it in an advanced enhanced bodybuilder's PED cabinet".

 

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