T3(Liothytonine Sodium) Weight Loss CAS:6893-02-3

Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Both hormones are stored in the thyroid colloid as thyroglobulin.

Thyroid hormone preparations belong to two categories: (1) natural hormonal preparations derived from animal thyroid, and (2) synthetic preparations. Natural preparations include desiccated thyroid and thyroglobulin. Desiccated thyroid is derived from domesticated animals that are used for food by man (either beef or hog thyroid), and thyroglobulin is derived from thyroid glands of the hog. The United States Pharmacopeia (USP) has standardized the total iodine content of natural preparations. Thyroid USP contains not less than (NLT) 0.17 percent and not more than (NMT) 0.23 percent iodine, and thyroglobulin contains not less than (NLT) 0.7 percent of organically bound iodine. Iodine content is only an indirect indicator of true hormonal biologic activity.

Liothyronine sodium tablets contain liothyronine (L-triiodothyronine or LT3), a synthetic form of a natural thyroid hormone, and is available as the sodium salt.

L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-,monosodium salt

Twenty-five mcg liothyronine is equivalent to approximately 1 grain of desiccated thyroid or thyroglobulin and 0.1 mg of L-thyroxine.

Inactive ingredients consist of calcium sulfate dihydrate, corn starch, gelatin, magnesium stearate and mannitol.

 

 

 

The mechanisms by which thyroid hormones exert their physiologic action are not well understood. These hormones enhance oxygen consumption by most tissues of the body, increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system.

Liothyronine, known by the brand name Cytomel and Triostat, is the synthetic form of T3.

The problem with T3 is that it has a very short lifespan, so it needs to be taken twice a day. T3 levels fluctuate in the body; when T3 levels are high, symptoms of hyperthyroidism often occur.

Symptoms of hyperthyroidism include a fast heart rate, insomnia, and anxiety. A type of heart arrhythmia called atrial fibrillation and bone loss (osteoporosis) may also occur.

 

 

Since liothyronine sodium (T3) is not firmly bound to serum protein, it is readily available to body tissues. The onset of activity of liothyronine sodium is rapid, occurring within a few hours. Maximum pharmacologic response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2-1/2 days.

T3 is almost totally absorbed, 95 percent in 4 hours. The hormones contained in the natural preparations are absorbed in a manner similar to the synthetic hormones.

Liothyronine sodium has a rapid cutoff of activity which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur.

The higher affinity of levothyroxine (T4) for both thyroid-binding globulin and thyroid-binding prealbumin as compared to triiodothyronine (T3) partially explains the higher serum levels and longer half-life of the former hormone. Both protein-bound hormones exist in reverse equilibrium with minute amounts of free hormone, the latter accounting for the metabolic activity.

 

 

Thyroid hormone drugs are indicated:

1) As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema and ordinary hypothyroidism in patients of any age (pediatric patients, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see WARNINGS).

2) As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's) and multinodular goiter.

3) As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

Liothyronine sodium tablets can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.

 

 

Trade names	Cytomel, Tertroxin
CAS	6893-02-3
Molar mass	672.959
Formula	C15H11I3NNaO4
Purity	Above 98%
Apprarance	25mcg*100，40mcg*100

 

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T3 liothyronine sodium, commonly known as liothyronine or triiodothyronine, is a synthetic form of the thyroid hormone triiodothyronine. It is used for medical purposes to treat conditions related to thyroid hormone deficiency, particularly when the thyroid gland is unable to produce enough of this hormone naturally. Here are some of the main uses of T3 liothyronine sodium:

Hypothyroidism: T3 liothyronine sodium is prescribed to individuals with hypothyroidism, a condition in which the thyroid gland does not produce sufficient thyroid hormones (T3 and T4). By supplementing with liothyronine, it helps restore normal thyroid hormone levels in the body, alleviating the symptoms of hypothyroidism, which may include fatigue, weight gain, cold intolerance, and depression.

Thyroid Cancer: In some cases, T3 liothyronine sodium may be used as part of the treatment for thyroid cancer. After thyroidectomy (surgical removal of the thyroid gland), thyroid hormone replacement therapy is necessary to maintain stable hormone levels in the body.

Thyroid Function Tests: T3 liothyronine sodium can also be used in diagnostic thyroid function tests to assess the thyroid's ability to produce hormones. It may be administered to evaluate thyroid function in certain medical conditions or to monitor the effectiveness of thyroid hormone replacement therapy.

It's important to note that T3 liothyronine sodium is a potent thyroid hormone medication and should only be used under the guidance and supervision of a healthcare professional. The dosage and treatment plan should be tailored to each individual's specific needs, and regular monitoring of thyroid function is typically required during treatment.

 

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