Rapid absorption after oral administration, with a median time of 2 hours after administration reaching the average maximum observed plasma concentration (cmax). The absolute bioavailability of this product after oral administration is not yet clear. The absorption rate and degree of Tadalafil are not affected by food, so this product can be taken with or without food. The time of administration (morning or evening) has no clinically significant effect on the absorption rate and degree. The average distribution volume is about 63 liters, indicating that Tadalafil is distributed into the tissues. At the therapeutic concentration, 94% of Tadalafil in plasma is bound to protein. Protein binding is not affected by renal dysfunction. In healthy subjects, the average clearance rate of oral Tadalafil was 2.5 L/hr, and the average half-life was 17.5 hours. Tadalafil was mainly excreted in the form of inactive metabolites, mainly from feces (about 61% of the dose), and a small part was excreted in urine (about 36% of the dose).
