Clinical evidence shows that Ostarine (also known as Enobosarm or MK-2866) can effectively increase muscle mass.
As an investigational selective androgen receptor modulator (SARM), Ostarine was originally developed to treat muscle-wasting conditions. Its mechanism of action involves selectively binding to and activating androgen receptors in muscle and bone, thereby promoting muscle protein synthesis, increasing lean body mass, and improving physical function. Multiple clinical studies support its efficacy:
●In healthy individuals: A 12-week randomized trial in 88 postmenopausal women found that the group receiving 3 mg of Ostarine daily gained an average of 1.54 kg more lean body mass (muscle mass) than the placebo group, along with an average 22‑lb increase in leg strength. Another study in elderly men showed that Ostarine increased lean body mass and improved stair‑climbing power by over 15%.
●In disease populations: A Phase II trial in 159 cancer patients with cachexia (severe muscle wasting) demonstrated that Ostarine treatment led to statistically significant improvements in lean body mass and physical function (measured by stair‑climbing time and power) over 16 weeks.
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