Mesterolone

Mesterolone, sold under the brand name Proviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels. It has also been used to treat male infertility, although this use is controversial. It is taken by mouth.

Mesterolone, also known by its brand name Proviron, is an orally active synthetic androgen and derivative of dihydrotestosterone (DHT). It is primarily used in the medical field for the treatment of conditions related to low testosterone levels.

Mesterolone is prescribed to men who have low testosterone levels, which can occur due to various factors such as hypogonadism or infertility. It works by supplementing the body with androgens, which are the male sex hormones, to restore normal testosterone levels. This can help improve symptoms such as low libido, erectile dysfunction, and fatigue associated with low testosterone.

Unlike many other anabolic steroids, mesterolone does not have strong anabolic effects, meaning it does not promote significant muscle growth. It is instead known for its anti-estrogenic properties. Mesterolone binds to the aromatase enzyme, inhibiting the conversion of testosterone into estrogen. This can be beneficial in preventing or reducing estrogen-related side effects, such as water retention and gynecomastia (enlargement of breast tissue in males), that can occur with the use of other steroids.

Mesterolone is generally well-tolerated when used as prescribed under medical supervision. However, it may still have potential side effects, including changes in mood, acne, oily skin, hair loss (in individuals predisposed to male pattern baldness), and suppression of natural testosterone production when used for extended periods. It is important to follow the prescribed dosage and duration of use to minimize these risks.

1) Mesterolone has a strong affinity for sex hormone binding globulin (SHBG). It increases the amount of circulating free testosterone by combining with SHBG, thus improving the testosterone level.

2) Mesterolone has been 5 α- Restore, it is not 5 α- The substrate of reductase, so it has no enhancement effect in skin, hair follicle, prostate and other tissues

3) Aromatase is also called estrogen synthetase, which is the key enzyme of estrogen biosynthesis. Mesterolone is not the substrate of aromatase, so it cannot be converted into estrogen. Estrogen can cause breast development and fluid retention in men.

 

 

 

Mesterolone is used in the treatment of androgen deficiency in male hypogonadism, anemia, and to support male fertility among other indications. It has also been used to treat delayed puberty in boys. Because it lacks estrogenic effects, mesterolone may be indicated for treating cases of androgen deficiency in which breast tenderness or gynecomastia is also present. The drug is described as a relatively weak androgen with partial activity and is rarely used for the purpose of androgen replacement therapy, but is still widely used in medicine.

Mesterolone is used in androgen replacement therapy at a dosage of 50 to 100 mg 2 to 3 times per day.

 

 

Mesterolone has been used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters.

 

 

The C1α methyl group of mesterolone inhibits its hepatic metabolism and thereby confers significant oral activity, although its oral bioavailability is still much lower than that of 17α-alkylated AAS. In any case, mesterolone is one of the few non-17α-alkylated AAS that is active with oral ingestion. Uniquely among AAS, mesterolone has very high affinity for human serum sex hormone-binding globulin (SHBG), about 440% that of DHT in one study and 82% of that of DHT in another study. As a result, it may displace endogenous testosterone from SHBG and thereby increase free testosterone concentrations, which may in part be involved in its effects.

 

 

In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed. In patients with dysthymia, unipolar, and bipolar depression significant improvement was observed. In this series of studies, mesterolone lead to a significant decrease in luteinizing hormone and testosterone levels. In another study, 100 mg mesterolone cipionate was administered twice monthly.With regards to plasma testosterone levels, there was no difference between the treated versus untreated group, and baseline luteinizing hormone levels were minimally affected.

 

 

Product Name	Mesterolone
Other Name	Proviron
CAS	1424-00-6
MW	304.47
MF	C20H32O2
Purity	Above 98%
Apprarance	White crystalline powder
Packing	100g/bag(Aluminum foil bag packaging)
MOQ	100G

 

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