Stanolone

Stanolone, also known as dihydrotestosterone (DHT), is a potent androgenic hormone and anabolic steroid. It is derived from testosterone through the action of the 5-alpha reductase enzyme.

Androstanolone, or stanolone, also known as dihydrotestosterone (DHT) and sold under the brand name Andractim among others, is an androgen and anabolic steroid (AAS) medication and hormone which is used mainly in the treatment of low testosterone levels in men. It is also used to treat breast development and small penis in males. It is typically given as a gel for application to the skin, but can also be used as an ester by injection into muscle.

 

 

Androstanolone is available in pharmaceutical formulations for medical use as an androgen. It is used mainly as a form of androgen replacement therapy in the treatment of male hypogonadism and is specifically approved for this indication in certain countries. However, it is no longer recommended for this purpose due to biological differences from testosterone such as lack of estrogenic effects and partial androgenic effects. Topical androstanolone is useful in the treatment of gynecomastia. Similarly, androstanolone enanthate via intramuscular injection has been found to be effective in the treatment persistent pubertal gynecomastia. The medication has also been used as a topical gel to treat small penis in pre- and peripubertal boys with mild or partial androgen insensitivity syndrome.

Androstanolone is available in pharmaceutical formulations for medical use as an androgen. It is used mainly as a form of androgen replacement therapy in the treatment of male hypogonadism and is specifically approved for this indication in certain countries. However, it is no longer recommended for this purpose due to biological differences from testosterone such as lack of estrogenic effects and partial androgenic effects. Topical androstanolone is useful in the treatment of gynecomastia. Similarly, androstanolone enanthate via intramuscular injection has been found to be effective in the treatment persistent pubertal gynecomastia. The medication has also been used as a topical gel to treat small penis in pre- and peripubertal boys with mild or partial androgen insensitivity syndrome.

Absorption：The bioavailability of androstanolone differs considerably depending on its route of administration.Its oral bioavailability is very low, and androstanolone has been considered to be ineffective by the oral route.However, it has been used orally, and is described as a weak AAS by this route. The transdermal bioavailability of androstanolone is approximately 10%. Its bioavailability with intramuscular injection, on the other hand, is complete (100%).

Doses of topical androstanolone gel of 16, 32, and 64 mg have been found to produce total testosterone and DHT levels in the low, mid, and high normal adult male range, respectively.

Distribution: The plasma protein binding of androstanolone is about 98.5 to 99.0%.It is bound 50 to 80% to sex hormone-binding globulin, 20 to 40% to albumin, and less than 0.5% to corticosteroid-binding globulin, with about 1.0 to 1.5% circulating freely or unbound.

Metabolism: The terminal half-life of androstanolone in the circulation (53 minutes) is longer than that of testosterone (34 minutes), and this may account for some of the difference in their potency. A study of transdermal androstanolone and testosterone therapy reported terminal half-lives of 2.83 hours and 1.29 hours, respectively.

Trade names	Andractim
Other Name	Stanolone; Dihydrotestosterone; DHT; 5α-Dihydrotestosterone; 5α-DH
CAS	521-18-6
Molar mass	290.447
MF	C19H30O2
Purity	Above 98%
Apprarance	White crystalline powder

 

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Stanolone (dihydrotestosterone) is a potent androgenic hormone and anabolic steroid. While it is not commonly used for medical purposes, there are a few specific applications where Stanolone may be utilized:

Androgen Replacement Therapy (ART): In rare cases, Stanolone may be prescribed as a form of androgen replacement therapy in individuals with a deficiency or absence of endogenous testosterone or other androgens. This is typically done under close medical supervision and for spec ific medical conditions.

Research and Experimental Use: Stanolone is frequently used in scientific research, particularly in studies related to androgen receptors, androgen signaling pathways, and other aspects of endocrinology and physiology. It provides researchers with a tool to explore and understand androgen-related processes.

Enhanced Muscle Hardness and Definition: DHT-based compounds can provide a "hardening" effect to the muscles. They can help reduce water retention and promote a lean, chiseled appearance, which is desirable for bodybuilders during competition preparation.

Increased Strength and Power: DHT derivatives are known for their strong androgenic properties, which can lead to significant increases in strength and power. This can enhance performance during weightlifting and other strength-based exercises.

Minimized Estrogenic Side Effects: DHT-based compounds do not convert to estrogen through aromatization, unlike some other anabolic steroids. This means they carry a lower risk of estrogen-related side effects, such as water retention and gynecomastia (en Larger breast tissue in males).

Reduced Risk of Androgenic Side Effects: DHT derivatives tend to have a lower tendency for certain androgenic side effects, such as bloating, acne, and hair loss, compared to other anabolic steroids. This can be advantageous for individuals who are sensitive to such effects.

Rapid Clearance from the Body: DHT-based compounds typically have a shorter half-life and clearance time compared to other anabolic steroids. This can be useful for athletes who want to minimize the detection window for drug tests.

 

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