High-Quality STROMUSC Aicar 10mg For Bodybuilding CAS:3031-94-5
Aicar—scientifically known as 5-aminoimidazole-4-carboxamide ribonucleotide, also referred to as acadesine or ZMP—is a nucleoside analog that occurs naturally as an intermediate metabolite in the de novo synthesis pathway of inosine monophosphate. In the bodybuilding and performance enhancement communities, it has gained notoriety as a so-called "exercise mimetic"—a compound that purportedly replicates the metabolic adaptations of endurance training without the physical exertion.
What Is Aicar?
Aicar-scientifically known as 5-aminoimidazole-4-carboxamide ribonucleotide, also referred to as acadesine or ZMP-is a nucleoside analog that occurs naturally as an intermediate metabolite in the de novo synthesis pathway of inosine monophosphate. In the bodybuilding and performance enhancement communities, it has gained notoriety as a so-called "exercise mimetic"-a compound that purportedly replicates the metabolic adaptations of endurance training without the physical exertion.
The compound works by activating AMP-activated protein kinase (AMPK), an enzyme frequently described as the cell's "master energy sensor". When AMPK is activated, it triggers a cascade of metabolic changes that mirror those occurring during prolonged aerobic exercise: increased fatty acid oxidation, enhanced glucose uptake, mitochondrial biogenesis, and a shift in muscle fiber characteristics toward fatigue-resistant slow-twitch fibers.
What makes Aicar particularly intriguing-and controversial-is its origin story. In a landmark 2008 study published in Cell, researchers demonstrated that sedentary mice receiving Aicar for four weeks showed a 44% improvement in running endurance without any exercise training. This finding captured global attention and led to the compound's rapid classification as a prohibited substance by the World Anti-Doping Agency (WADA) in 2009.
The 10mg Tablet Formulation
Top-quality Aicar 10mg tablets represent an oral delivery format of this AMPK-activating compound. Each tablet contains 10 milligrams of the active ingredient acadesine, typically packaged in containers of 60 capsules. The tablet format is marketed as a dietary supplement intended to enhance aerobic endurance, promote fat oxidation, and support metabolic efficiency.
However, a critical caveat must be acknowledged upfront: oral bioavailability of Aicar is exceptionally poor. Research indicates that oral bioavailability is estimated at less than 5% in humans. This means that from a 10mg oral dose, only a fraction-likely less than half a milligram-actually reaches systemic circulation. This pharmacokinetic reality has led many researchers to question whether oral tablet formulations can deliver meaningful physiological effects. The compound's poor oral bioavailability, short half-life, and tendency to elevate circulating lactic acid and uric acid levels have historically limited its therapeutic potential.
Mechanism of Action: How It Works
To understand what Aicar 10mg tablets purportedly do, one must first grasp the AMPK pathway. Inside cells, Aicar is phosphorylated by adenosine kinase to form ZMP (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate). ZMP structurally mimics AMP and binds to the gamma regulatory subunit of AMPK, allosterically activating the kinase without requiring actual energy depletion.
Once activated, AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), relieving the inhibition of carnitine palmitoyltransferase I (CPT-1). This dramatically increases mitochondrial fatty acid oxidation-the body's ability to burn fat for fuel. Simultaneously, AMPK stimulates glucose uptake by promoting GLUT4 translocation to the cell membrane, independent of insulin signaling. It also activates PGC-1α, the master regulator of mitochondrial biogenesis, increasing both the number and function of mitochondria within muscle cells.
The exercise-mimetic effects extend to muscle fiber type transformation. AMPK/PGC-1α activation shifts gene expression toward slow-twitch (Type I) oxidative fiber characteristics, increasing fatigue resistance and endurance capacity. This is where the compound's relevance to bodybuilding becomes nuanced-and contested.
Applications in Bodybuilding
The bodybuilding community has shown considerable interest in Aicar for several perceived applications:
Endurance Enhancement
The most cited application is aerobic endurance improvement. The 44% running endurance increase observed in sedentary mice has generated persistent interest. In practice, users report enhanced cardiovascular capacity during training sessions, allowing for longer and more intense workouts. This can translate to more productive cardio sessions during cutting phases and improved recovery between sets.
Fat Oxidation and Body Composition
By shifting metabolism toward fatty acid oxidation, Aicar is marketed as a fat-burning aid. The AMPK pathway activation promotes the release and oxidation of fatty acids. For bodybuilders in contest preparation or cutting cycles, this could theoretically support the preservation of lean mass while reducing body fat.
The Controversy: Muscle Growth
This is where the bodybuilding application becomes problematic. AMPK activation is generally antagonistic to the mTOR pathway, which drives muscle protein synthesis and hypertrophy. Research has demonstrated that Aicar-induced AMPK activation negatively regulates myotube hypertrophy. Studies show that Aicar treatment decreases HSP72 protein expression and inhibits myotube formation. Furthermore, Aicar-induced AMPK phosphorylation inhibits cell cycle transition and reduces differentiation of myoblasts into myotubes.
In plain terms: the same mechanism that enhances endurance and fat oxidation may directly oppose muscle growth. This creates a fundamental conflict for bodybuilders whose primary goal is hypertrophy. Some forum discussions reflect this tension, with users noting that Aicar "switches fast-twitch fibers to slow-twitch"-a transformation that may benefit endurance athletes but could be detrimental for power and size-focused bodybuilders.
Dosage Protocols
Dosing Aicar 10mg tablets requires careful consideration. Various sources suggest different approaches:
Beginner Protocol (4-6 weeks):
For individuals new to the compound, a starting dose of 5-10mg daily is commonly recommended. After one to two weeks, the dose may be increased to 20mg daily based on tolerance and observed results.
Standard Protocol (4-6 weeks):
Depending on individual goals, daily dosing typically ranges from 10-50mg. Some sources suggest 10-30mg daily for beginners and 30-50mg daily for advanced users.
Cycle Duration:
The standard cycle length is 4-6 weeks. Some protocols extend to 8 weeks. Cycling is recommended to prevent the body from adapting to the compound and to maximize benefits.
Administration Timing:
Optimal administration is on an empty stomach, typically in the morning or before training.
Important Consideration:
It bears repeating that research-grade Aicar protocols in animal studies have used doses of 150-500mg subcutaneously or intravenously. The 10-50mg oral doses used in bodybuilding circles are orders of magnitude lower and, given the poor oral bioavailability, may produce minimal physiological effects. As one community discussion noted, "Even 10mg a day will run you a considerable amount of money in the long run and this is not even known to be an effective dosage".
Half-Life and Pharmacokinetics
The plasma half-life of Aicar has been characterized as biphasic, with a terminal half-life of approximately 41.4 minutes. Total clearance is approximately 15.4 ml/kg·min, indicating that about 50% is eliminated by extrarenal mechanisms.
Other sources suggest a half-life of approximately 2-3 hours in humans. After approximately four to five half-lives (roughly 8-15 hours), the compound would be largely eliminated from the system.
The short half-life presents practical challenges for oral tablet administration. To maintain effective concentrations, frequent dosing would be required-yet oral bioavailability remains the primary bottleneck. The compound also does not efficiently cross the blood-brain barrier.
Post-Cycle Therapy: A Misconception
A critical point of clarification: Aicar is not a hormone. It does not suppress endogenous testosterone production, nor does it affect the hypothalamic-pituitary-gonadal axis. Therefore, traditional post-cycle therapy (PCT) involving SERMs like tamoxifen or clomiphene is not applicable or necessary for Aicar use.
However, some sources suggest a "PCT" period of 75-150 IU of HCG every other day for 1-2 weeks. This likely reflects confusion with other compounds or represents a cautious approach to overall hormonal balance following a cycle of multiple substances.
What is more relevant is the concept of cycle off-periods. Given that AMPK activation can be antagonistic to anabolic pathways, and to prevent potential desensitization, users typically implement 2-4 week breaks between Aicar cycles. Some protocols recommend 2 weeks on, 2 weeks off, while others suggest 4-8 weeks on followed by comparable off periods.
Stacking Considerations
Aicar is frequently stacked with GW501516 (Cardarine), a PPARδ agonist. The combination has been shown to synergistically enhance endurance in animal studies. Both compounds operate through different but complementary metabolic pathways-AMPK activation versus PPARδ agonism.
For bodybuilders, stacking Aicar with other cutting agents such as T3 or traditional fat burners is also common. However, the addition of AMPK activators to an anabolic stack requires careful consideration of the potential interference with muscle growth pathways.
Side Effects and Safety Considerations
Aicar carries several documented and theoretical risks:
Hyperuricemia: Elevated uric acid levels are consistently reported, attributed to the compound's purine nucleoside structure. This could precipitate gout attacks in susceptible individuals.
Hypoglycemia Risk: AMPK-mediated enhancement of glucose uptake can cause blood sugar drops, particularly in fasted individuals or those with metabolic sensitivity.
The Reality Check
For the bodybuilder considering Aicar 10mg tablets, several truths must be confronted:
First, the 44% endurance improvement was observed in sedentary mice at doses of 500mg/kg-a dose that would translate to grams per day in humans. The 10-50mg oral doses used by bodybuilders are a fraction of what was studied.
Second, human data is virtually nonexistent. As one source notes, "Humans have never been adequately tested for AICAR's endurance effects, so calling it an exercise mimetic is speculative".
Third, the compound's mechanism directly opposes the primary goal of most bodybuilders: muscle hypertrophy. The AMPK pathway that Aicar activates is fundamentally catabolic in the context of muscle protein synthesis.
Clinical Data
|
Brand |
STROMUSC |
|
Trade names |
Aminoimidazole carboxamide ribonucleotide, AICA ribonucleotide, ZMP |
|
CAS |
3031-94-5 |
|
Molar mass |
338.213 |
|
MF |
C9H15N4O8P |
|
Purity |
Above 98% |
|
Apprarance |
10mg*100/bottle |
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Conclusion
Top-quality Aicar 10mg tablets represent a fascinating intersection of metabolic science and bodybuilding experimentation. The compound's ability to activate AMPK and mimic certain exercise adaptations is well-documented in preclinical research. However, the translation to human use-particularly oral tablet administration at the doses commonly employed-remains highly questionable.
For the endurance athlete, the theoretical benefits may hold more relevance. For the bodybuilder seeking hypertrophy, the metabolic pathway activation may be counterproductive.
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