High-Quality STROMUSC Androxal(Enclomiphene)25mg For Bodybuilding CAS:15690-57-0

  What Is Androxal (Enclomiphene)?

   Androxal is the brand name under which enclomiphene citrate was developed and investigated as a treatment for secondary hypogonadism in men. To understand enclomiphene, one must first understand its relationship to clomiphene citrate-the drug more commonly known as Clomid.

    Clomiphene citrate is a racemic mixture of two distinct isomers: enclomiphene (the trans-isomer) and zuclomiphene (the cis-isomer). For decades, Clomid has been used in fertility medicine and, in bodybuilding circles, as a post-cycle therapy agent. However, the two isomers exert dramatically different effects on the body. Enclomiphene acts primarily as an estrogen receptor antagonist-it blocks estrogen receptors without activating them. Zuclomiphene, by contrast, acts as a partial agonist and has a propensity to accumulate in tissues with chronic use.

    Androxal was developed to isolate and deliver only the active, beneficial isomer-enclomiphene-while eliminating the zuclomiphene component that contributes to many of the side effects associated with Clomid. The drug completed Phase II and III clinical trials but ultimately did not receive FDA approval; the agency issued a Complete Response Letter in 2015 citing concerns about study design adequacy. Despite this regulatory outcome, enclomiphene remains available through compounding pharmacies on a prescription basis and has generated substantial interest in the bodybuilding community.

    Isomer Purity

    The most fundamental feature of Androxal is its status as a pure enclomiphene preparation. Traditional Clomid contains approximately 60% enclomiphene and 40% zuclomiphene. This means that a 50mg dose of Clomid delivers only about 30mg of the active testosterone-stimulating isomer alongside 20mg of the zuclomiphene isomer, which has been implicated in mood disturbances, vision issues, and prolonged washout periods. Androxal 25mg delivers 25mg of pure, active enclomiphene without the accompanying baggage of its inactive counterpart.

    Oral Bioavailability

    Enclomiphene is administered orally, offering a significant practical advantage over injectable testosterone preparations. The compound demonstrates high oral bioavailability and can be taken once daily without the need for fasting or strict timing considerations. This makes it accessible for individuals who prefer to avoid injections or who travel frequently.

    Targeted Mechanism

    Unlike exogenous testosterone, which suppresses the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback, enclomiphene works with the body's natural regulatory systems. It blocks estrogen receptors in the hypothalamus, effectively "blindfolding" the brain to circulating estradiol levels. This interference with the negative feedback loop allows gonadotropin-releasing hormone (GnRH) pulsatility to resume, which in turn stimulates the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then drive the testes to produce endogenous testosterone.

    Fertility Preservation

    Perhaps the most clinically significant feature of enclomiphene-and one that distinguishes it sharply from exogenous testosterone-is its preservation of fertility. While testosterone replacement therapy suppresses spermatogenesis through the shutdown of LH and FSH, enclomiphene actually maintains or even improves sperm production. This has made it particularly attractive to men who wish to optimize their hormonal status while retaining reproductive capacity.

    Post-Cycle Therapy (PCT)

    The primary application of Androxal in bodybuilding is as a post-cycle therapy agent. After a cycle of anabolic-androgenic steroids or selective androgen receptor modulators (SARMs), the body's natural testosterone production is typically suppressed. Enclomiphene is employed to "kickstart" the HPG axis, restoring endogenous testosterone production and helping the athlete retain the muscle mass gained during the cycle.

    Clinical research has demonstrated enclomiphene's efficacy in this regard. Studies in men with secondary hypogonadism showed that enclomiphene raised mean testosterone from approximately 205 ng/dL to 413–446 ng/dL at 16 weeks. Dose-response data indicate that 25mg produces a mean increase of approximately +360 ng/dL versus baseline, though diminishing returns are observed at higher doses.

    "Natural" Testosterone Optimization

    Some bodybuilders and fitness enthusiasts use enclomiphene as a form of "natural" testosterone optimization-a strategy sometimes referred to as a "natural TRT" protocol. Rather than committing to lifelong exogenous testosterone administration, these individuals use enclomiphene to elevate their endogenous testosterone levels while maintaining HPG axis function.

    Clinical data support the feasibility of this approach. In Phase III trials, enclomiphene maintained testosterone levels at ≥550 ng/dL in treated men without reducing sperm counts. The compound effectively functions as a gonadotropin stimulator, raising LH and FSH rather than suppressing them.

    On-Cycle Support

    A more niche application involves using enclomiphene during a cycle of suppressive compounds to mitigate testicular shutdown. While enclomiphene cannot fully overcome the suppression induced by high-dose exogenous androgens, it may preserve some degree of testicular function and prevent complete atrophy. This strategy is more commonly employed with milder compounds or SARMs cycles where suppression is less profound.

    Endogenous Testosterone Elevation

    The primary benefit is straightforward: significant, clinically validated increases in endogenous testosterone production. The 25mg dose has been shown to produce mean increases of 360 ng/dL or more, with some individuals experiencing even more dramatic elevations.

    Muscle Protein Synthesis and Recovery

    Elevated testosterone levels are directly associated with increased muscle protein synthesis, improved recovery from training, and favorable changes in body composition. By raising endogenous testosterone through physiological pathways, enclomiphene supports the anabolic environment necessary for muscle growth and maintenance.

    Preservation of Natural Axis Function

    Unlike exogenous testosterone, which requires ongoing administration and can lead to testicular atrophy and prolonged suppression, enclomiphene preserves the natural feedback loops of the HPG axis. This means that users can potentially discontinue treatment without experiencing the profound "crash" associated with coming off exogenous androgens.

    Absence of Estrogenic Side Effects

    Because enclomiphene is the pure trans-isomer without the zuclomiphene component, it does not exhibit the estrogenic agonist activity that plagues Clomid. This translates to a cleaner side-effect profile with fewer instances of mood disturbances, emotional volatility, and visual disturbances.

    Standard Dosing for PCT

    The most common protocol for post-cycle therapy employs 12.5–25mg daily for a duration of 4–6 weeks. The 25mg dose is typically used at the beginning of PCT, with some protocols tapering to 12.5mg in the later weeks.

    Low-Dose Maintenance

    For long-term use or as a TRT alternative, lower doses are generally employed. Clinical protocols and community experience suggest that 6.25–12.5mg daily is sufficient for maintenance purposes, with 12.5mg frequently cited as the "community sweet spot".

    Dose-Response Considerations

    It is worth noting that the relationship between dose and response is not linear. Dose-response data suggest diminishing returns at higher doses, with the 25mg group showing only modestly higher testosterone increases than the 12.5mg group. This suggests that 25mg may be more than necessary for many individuals, and that starting with a lower dose and titrating upward based on bloodwork is a prudent approach.

    PCT Protocol Timing

    For post-cycle therapy following a steroid cycle, enclomiphene is typically initiated after the exogenous compounds have cleared from the system. For long-ester injectables, this means waiting approximately 2–3 weeks after the last injection. For shorter-acting compounds or SARMs, PCT can begin sooner.

    Duration

    The standard PCT duration is 4–6 weeks. Some protocols extend to 8 weeks for individuals who have been on particularly suppressive or prolonged cycles. Bloodwork should guide the duration; treatment can be discontinued once testosterone levels have normalized and LH/FSH have recovered.

    Monitoring

    Regular bloodwork is essential during enclomiphene use. Key markers to monitor include total and free testosterone, estradiol, LH, FSH, and hematocrit. This allows for dose adjustment and early detection of any adverse trends.

    The half-life of enclomiphene is a subject of some discussion in the literature, with estimates varying based on the measurement methodology.

    Short Half-Life Estimates

    Some sources report a half-life of approximately 5–7 hours for enclomiphene, while others cite approximately 10 hours. This is notably shorter than the half-life of zuclomiphene, which can persist in the body for extended periods.

    24-Hour Active Duration

    Despite the relatively short half-life, the active duration of enclomiphene's effects extends to approximately 24 hours. This supports once-daily dosing, as the compound's impact on the hypothalamic-pituitary axis persists beyond its mere presence in the bloodstream.

    Implications for Dosing

    The short half-life means that enclomiphene does not accumulate significantly with repeated dosing, reducing the risk of prolonged side effects or extended washout periods. It also means that steady-state levels are achieved relatively quickly, allowing for rapid adjustment of protocols based on response.

    Detection Times

    While the half-life is short, detection times can be considerably longer. Clomid has been detected in studies for up to 4 months, though enclomiphene specifically may have a shorter detection window. Athletes subject to anti-doping regulations should be aware that enclomiphene is banned by WADA under the SERM classification.

    A typical PCT protocol using enclomiphene 25mg tablets proceeds as follows:

    Weeks 1–2: 25mg daily. This higher initial dose serves to rapidly stimulate LH and FSH production, "shocking" the suppressed HPG axis back into activity.

    Weeks 3–4: 12.5mg daily. As the axis begins to recover, the dose is reduced to minimize the risk of over-stimulation and to allow for a gradual transition back to homeostasis.

    Weeks 5–6 (optional): 12.5mg every other day or 6.25mg daily. Some protocols include a tapering phase to further smooth the transition.

    Combination with HCG

    Some protocols combine enclomiphene with human chorionic gonadotropin (HCG) for a more comprehensive PCT approach. HCG mimics LH and directly stimulates the testes, while enclomiphene works at the hypothalamic-pituitary level. This dual approach may be particularly beneficial for individuals who have been on long-term suppressive cycles.

    Monotherapy Approach

    For individuals using enclomiphene as a TRT alternative rather than for PCT, a continuous low-dose protocol is employed. Doses of 6.25–12.5mg daily or 12.5mg every other day are commonly used. Regular bloodwork is essential to ensure that testosterone levels remain in the desired range without excessive estradiol elevation.

    Enclomiphene is generally well-tolerated, but side effects can occur. The most commonly reported include headaches, nausea, hot flashes, and mild mood changes. These are typically mild and self-limited.
    A significant limitation of enclomiphene is the absence of robust long-term safety data. Most clinical trials were of relatively short duration (months rather than years), and the chronic use that some individuals pursue extends beyond the evidence base.

    The distinction between enclomiphene and clomiphene citrate is not merely academic-it has practical implications for users.

    Efficacy

    Enclomiphene is the active isomer responsible for testosterone stimulation. Studies have shown that the 25mg dose of Androxal produced mean improvements in testosterone of 259.2 ng/dL, which is significantly higher than either Clomid or Nolvadex is likely to produce. In practical terms, enclomiphene is more potent milligram-for-milligram than Clomid.

    Side Effect Profile

    Because enclomiphene lacks the zuclomiphene isomer, it is associated with fewer estrogenic side effects. Users report the testosterone-restoring benefits of Clomid without the mood crashes, vision shimmer, and weeks-long washout that made traditional Clomid PCTs problematic.

    Half-Life

    Enclomiphene has a significantly shorter half-life than zuclomiphene, which means it does not accumulate in tissues with repeated dosing. This translates to faster achievement of steady-state levels and more predictable pharmacokinetics.

    It is important to understand that Androxal-enclomiphene-is not FDA-approved. The drug was developed by Repros Therapeutics and submitted for approval, but the FDA issued a Complete Response Letter in 2015. The agency cited concerns about study design adequacy and recommended additional Phase 3 studies that were never completed.

    Despite this regulatory outcome, enclomiphene is available through compounding pharmacies on a prescription basis. It is also available from various international sources, though quality and purity can vary significantly.

Brand	STROMUSC
Trade names	Androxal; EnCyzix;Enclomiphene; (E)-Clomifene; RMI-16289; Enclomid; Enclomifene citrate; Enclomiphene citrate
CAS	15690-57-0
Molar mass	405.97
MF	C26H28ClNO
Purity	Above 98%
Apprarance	25mg*100

 

 

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    Androxal (enclomiphene) 25mg tablets represent a sophisticated approach to testosterone optimization that stands in stark contrast to traditional exogenous hormone administration. By working with the body's natural regulatory systems rather than bypassing them, enclomiphene offers the potential for significant testosterone elevation while preserving fertility and HPG axis function.

    For bodybuilders, the applications are clear: as a post-cycle therapy agent, enclomiphene provides a cleaner, more targeted alternative to Clomid, with a superior side-effect profile and greater potency. As a TRT alternative, it offers the possibility of testosterone optimization without committing to lifelong exogenous administration.

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